Synonym
Isoflurophate, Diisopropyl fluorophosphate, Fluostigmine, Dyflos, Neoglaucit, PF-3
IUPAC/Chemical Name
2-[fluoro(propan-2-yloxy)phosphoryl]oxypropane
InChi Key
MUCZHBLJLSDCSD-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
SMILES Code
CC(OP(OC(C)C)(F)=O)C
Appearance
Clear Colorless to Light Yellow Oil
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
184.15
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hadjiconstantinou M, Hubble JP, Wemlinger TA, Neff NH. Enhanced MPTP neurotoxicity after treatment with isoflurophate or cholinergic agonists. J Pharmacol Exp Ther. 1994 Aug;270(2):639-44. PubMed PMID: 7915317.
2: Michalek H, Meneguz A, Bisso GM. Mechanisms of recovery of brain acetylcholinesterase in rats during chronic intoxication by isoflurophate. Arch Toxicol Suppl. 1982;5:116-9. PubMed PMID: 6954889.
3: Meneguz A, Bisso GM, Michalek H. Regional differences in brain-soluble acetylcholinesterase and its molecular forms after acute poisoning by isoflurophate in rats. Clin Toxicol. 1981 Dec;18(12):1443-51. PubMed PMID: 7333079.
4: Bunke A, Bito LZ. Gradual increase in the sensitivity of extraocular muscles to acetylcholine during topical treatment of rabbit eyes with isoflurophate. Am J Ophthalmol. 1981 Aug;92(2):259-67. PubMed PMID: 7270643.
5: Ryan JA, McGaughran WR, Lindemann CJ, Zacchei AG. Separation and spectral properties of diisopropylphosphate, the major decomposition product of isoflurophate. J Pharm Sci. 1979 Sep;68(9):1194-5. PubMed PMID: 501553.
6: Wilensky JG, Dettbarn WD, Rosenberg P, De Roetth A Jr. Effect of ocular instillation of echothiophate iodide and isoflurophate on cholinesterase activity of various rabbit tissues. Am J Ophthalmol. 1967 Sep;64(3):398-404. PubMed PMID: 6036299.
7: Bedrossian EH, Krewson WE 3rd. Isoflurophate versus glasses in evaluating the accommodative element in esotropia. Arch Ophthalmol. 1966 Aug;76(2):186-8. PubMed PMID: 5945171.
8: WHEELER MC. ISOFLUROPHATE (DFP) IN THE HANDLING OF ESOTROPIA. Arch Ophthalmol. 1964 Mar;71:298-302. PubMed PMID: 14100750.
9: PONASSI A, MORRA L, BOCCACCIO P, GURRERI G, TIRELLI G. [CLINICAL STUDY OF EFFECTIVE SURVIVAL OF ERYTHROCYTES BY MEANS OF LABELLED ISOFLUROPHATE]. Haematologica. 1964;49:605-30. Italian. PubMed PMID: 14250005.
10: SLOAN LL, SEARS ML, JABLONSKI MD. Convergence-accommodation relationships. Description of a simple clinical test and its application to the evaluation of isoflurophate (DFP) therapy. Arch Ophthalmol. 1960 Feb;63:283-306. PubMed PMID: 13831681.
11: DAVIS B. Clinical experience with isoflurophate as an aid in orthoptic treatment. Am Orthopt J. 1960;10:108-12. PubMed PMID: 13814426.
12: SAETEREN T, ROE O. [Treatment of glaucoma simplex with isoflurophate (DFP)]. Tidsskr Nor Laegeforen. 1959 Feb 15;79(4):197-200. Norwegian. PubMed PMID: 13647528.
13: USE OF isoflurophate in strabismus. J Am Med Assoc. 1957 Jun 22;164(8):875. PubMed PMID: 13428564.
14: JANES RG, CALKINS JP. Effect of certain drugs on the iris vessels; the action of isoflurophate and homatropine on the rat's eye. AMA Arch Ophthalmol. 1957 Mar;57(3):414-7. PubMed PMID: 13410225.
