Synonym
Iobenguane, Adreview, Metaiodobenzylguanidine
IUPAC/Chemical Name
2-[(3-iodophenyl)methyl]guanidine
InChi Key
PDWUPXJEEYOOTR-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)
SMILES Code
N/C(N)=N\CC1=CC=CC(I)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
275.09
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Feola M, Chauvie S, Biggi A, Testa M. Role of (123)I-Iobenguane Myocardial Scintigraphy in Predicting Short-term Left Ventricular Functional Recovery: An Interesting Image. J Clin Imaging Sci. 2015 Oct 30;5:56. doi: 10.4103/2156-7514.168707. eCollection 2015. PubMed PMID: 26664773; PubMed Central PMCID: PMC4647125.
2: Chin BB, Kronauge JF, Femia FJ, Chen J, Maresca KP, Hillier S, Petry NA, James OG, Oldan JD, Armor T, Stubbs JB, Stabin MG, Babich JW. Phase-1 clinical trial results of high-specific-activity carrier-free 123I-iobenguane. J Nucl Med. 2014 May;55(5):765-71. doi: 10.2967/jnumed.113.124057. Epub 2014 Mar 13. PubMed PMID: 24627436.
3: Coleman RE, Stubbs JB, Barrett JA, de la Guardia M, Lafrance N, Babich JW. Radiation dosimetry, pharmacokinetics, and safety of ultratrace Iobenguane I-131 in patients with malignant pheochromocytoma/paraganglioma or metastatic carcinoid. Cancer Biother Radiopharm. 2009 Aug;24(4):469-75. doi: 10.1089/cbr.2008.0584. PubMed PMID: 19694582.
4: Cortés-Blanco A, Martínez Lázaro R, Vargas Castrillón E. [Authorized specifications for human use in clinical practice of radiopharmaceuticals composed of iobenguane (123I) marketed in Spain]. Rev Esp Med Nucl. 2008 Nov-Dec;27(6):468-74. Spanish. PubMed PMID: 19094909.
5: Hinkle GH, Dura JV, Morosco RS, Nahata MC. Extended stability of iobenguane under simulated clinical conditions. Am J Health Syst Pharm. 2008 Jan 15;65(2):142-4. doi: 10.2146/ajhp070247. PubMed PMID: 18192259.
