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MedKoo Cat#: 319863 | Name: Adoprazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Adoprazine, also known as SLV313, is a dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. SLV313 possessed high affinity at human recombinant D(2), D(3), D(4), 5-HT(2B), and 5-HT(1A) receptors, moderate affinity at 5-HT(7) and weak affinity at 5-HT(2A) receptors, with little-no affinity at 5-HT(4), 5-HT(6), alpha(1), and alpha(2) (rat), H(1) (guinea pig), M(1), M(4), 5-HT(3) receptors, and the 5-HT transporter. SLV313 had full agonist activity at cloned h5-HT(1A) receptors (pEC(50)=9.0) and full antagonist activity at hD(2) (pA(2)=9.3) and hD(3) (pA(2)=8.9) receptors.

Chemical Structure

Adoprazine
CAS#222551-17-9 (free base)

Theoretical Analysis

MedKoo Cat#: 319863

Name: Adoprazine

CAS#: 222551-17-9 (free base)

Chemical Formula: C24H24FN3O2

Exact Mass: 405.1853

Molecular Weight: 405.47

Elemental Analysis: C, 71.09; H, 5.97; F, 4.69; N, 10.36; O, 7.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SLV313; SLV-313; SLV 313; Adoprazine
IUPAC/Chemical Name
1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-((5-(4-fluorophenyl)-3-pyridinyl)methyl)piperazine
InChi Key
IUVSEUFHPNITEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H24FN3O2/c25-21-6-4-19(5-7-21)20-14-18(15-26-16-20)17-27-8-10-28(11-9-27)22-2-1-3-23-24(22)30-13-12-29-23/h1-7,14-16H,8-13,17H2
SMILES Code
FC1=CC=C(C2=CN=CC(CN3CCN(C4=C5OCCOC5=CC=C4)CC3)=C2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 222551-05-5 (Adoprazine hydrochloride ) 222551-17-9 (Adoprazine free base)

Preparing Stock Solutions

The following data is based on the product molecular weight 405.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Eur J Pharmacol. 2008 Sep 11;592(1-3):160-6. doi: 10.1016/j.ejphar.2008.06.105. Epub 2008 Jul 4. PubMed PMID: 18640111. 4: Jones CA, McCreary AC. Serotonergic approaches in the development of novel antipsychotics. Neuropharmacology. 2008 Nov;55(6):1056-65. doi: 10.1016/j.neuropharm.2008.05.025. Epub 2008 Jun 3. Review. PubMed PMID: 18621404. 5: Bruins Slot LA, Bardin L, Auclair AL, Depoortere R, Newman-Tancredi A. Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice. Behav Pharmacol. 2008 Mar;19(2):145-52. doi: 10.1097/FBP.0b013e3282f62cb2. PubMed PMID: 18332679. 6: Heusler P, Newman-Tancredi A, Loock T, Cussac D. Antipsychotics differ in their ability to internalise human dopamine D2S and human serotonin 5-HT1A receptors in HEK293 cells. Eur J Pharmacol. 2008 Feb 26;581(1-2):37-46. doi: 10.1016/j.ejphar.2007.11.046. Epub 2007 Nov 28. PubMed PMID: 18190908. 7: Newman-Tancredi A, Heusler P, Martel JC, Ormière AM, Leduc N, Cussac D. Agonist and antagonist properties of antipsychotics at human dopamine D4.4 receptors: G-protein activation and K+ channel modulation in transfected cells. Int J Neuropsychopharmacol. 2008 May;11(3):293-307. Epub 2007 Sep 26. PubMed PMID: 17897483. 8: Lange JH, Reinders JH, Tolboom JT, Glennon JC, Coolen HK, Kruse CG. Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs. J Med Chem. 2007 Oct 18;50(21):5103-8. Epub 2007 Sep 19. PubMed PMID: 17880057. 9: Bruins Slot LA, Palmier C, Tardif S, Cussac D. Action of novel antipsychotics at human dopamine D3 receptors coupled to G protein and ERK1/2 activation. Neuropharmacology. 2007 Aug;53(2):232-41. Epub 2007 May 21. PubMed PMID: 17588617. 10: Auclair AL, Galinier A, Besnard J, Newman-Tancredi A, Depoortère R. Putative antipsychotics with pronounced agonism at serotonin 5-HT1A and partial agonist activity at dopamine D2 receptors disrupt basal PPI of the startle reflex in rats. Psychopharmacology (Berl). 2007 Jul;193(1):45-54. Epub 2007 Mar 29. PubMed PMID: 17393144. 11: Bardin L, Auclair A, Kleven MS, Prinssen EP, Koek W, Newman-Tancredi A, Depoortère R. Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics. Behav Pharmacol. 2007 Mar;18(2):103-18. PubMed PMID: 17351418. 12: Heusler P, Newman-Tancredi A, Castro-Fernandez A, Cussac D. Differential agonist and inverse agonist profile of antipsychotics at D2L receptors coupled to GIRK potassium channels. Neuropharmacology. 2007 Mar;52(4):1106-13. Epub 2007 Jan 19. PubMed PMID: 17239906. 13: Assié MB, Dominguez H, Consul-Denjean N, Newman-Tancredi A. In vivo occupancy of dopamine D2 receptors by antipsychotic drugs and novel compounds in the mouse striatum and olfactory tubercles. Naunyn Schmiedebergs Arch Pharmacol. 2006 Sep;373(6):441-50. Epub 2006 Sep 1. PubMed PMID: 16947046. 14: Feenstra RW, van den Hoogenband A, Stroomer CN, van Stuivenberg HH, Tulp MT, Long SK, van der Heyden JA, Kruse CG. SAR study of 1-aryl-4-(phenylarylmethyl)piperazines as ligands for both dopamine D2 and serotonin 5-HT1A receptors showing varying degrees of (Ant)agonism. Selection of a potential atypical antipsychotic. Chem Pharm Bull (Tokyo). 2006 Sep;54(9):1326-30. PubMed PMID: 16946546. 15: McCreary AC, Glennon JC, Ashby CR Jr, Meltzer HY, Li Z, Reinders JH, Hesselink MB, Long SK, Herremans AH, van Stuivenberg H, Feenstra RW, Kruse CG. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology. 2007 Jan;32(1):78-94. Epub 2006 May 17. PubMed PMID: 16710314. 16: Cosi C, Carilla-Durand E, Assié MB, Ormiere AM, Maraval M, Leduc N, Newman-Tancredi A. Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release. Eur J Pharmacol. 2006 Mar 27;535(1-3):135-44. Epub 2006 Mar 22. PubMed PMID: 16554049. 17: Bruins Slot LA, De Vries L, Newman-Tancredi A, Cussac D. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534(1-3):63-70. Epub 2006 Feb 21. PubMed PMID: 16497294. 18: Auclair AL, Kleven MS, Besnard J, Depoortère R, Newman-Tancredi A. Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade. Neuropsychopharmacology. 2006 Sep;31(9):1900-9. Epub 2006 Jan 18. PubMed PMID: 16421514. 19: Bardin L, Kleven MS, Barret-Grévoz C, Depoortère R, Newman-Tancredi A. Antipsychotic-like vs cataleptogenic actions in mice of novel antipsychotics having D2 antagonist and 5-HT1A agonist properties. Neuropsychopharmacology. 2006 Sep;31(9):1869-79. Epub 2005 Oct 19. PubMed PMID: 16237379. 20: Bruins Slot LA, Kleven MS, Newman-Tancredi A. Effects of novel antipsychotics with mixed D(2) antagonist/5-HT(1A) agonist properties on PCP-induced social interaction deficits in the rat. Neuropharmacology. 2005 Dec;49(7):996-1006. Epub 2005 Jul 11. PubMed PMID: 16009387.