MedKoo Cat#: 319841 | Name: Sonedenoson

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sonedenoson, also known as MRE0094, is an adenosine A2A receptor agonist, which can effectively promote rapid wound healing. By stimulating adenosine A2A receptor, Sonedenoson increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1.

Chemical Structure

Sonedenoson
Sonedenoson
CAS#131865-88-8

Theoretical Analysis

MedKoo Cat#: 319841

Name: Sonedenoson

CAS#: 131865-88-8

Chemical Formula: C18H20ClN5O5

Exact Mass: 421.1153

Molecular Weight: 421.84

Elemental Analysis: C, 51.25; H, 4.78; Cl, 8.40; N, 16.60; O, 18.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MRE0094; MRE-0094; MRE 0094; Sonedenoson
IUPAC/Chemical Name
(2R,3R,4S,5R)-2-(6-amino-2-(4-chlorophenethoxy)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
InChi Key
WUCQGGOGHZRELS-LSCFUAHRSA-N
InChi Code
InChI=1S/C18H20ClN5O5/c19-10-3-1-9(2-4-10)5-6-28-18-22-15(20)12-16(23-18)24(8-21-12)17-14(27)13(26)11(7-25)29-17/h1-4,8,11,13-14,17,25-27H,5-7H2,(H2,20,22,23)/t11-,13-,14-,17-/m1/s1
SMILES Code
NC1=C2N=CN([C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O)C2=NC(OCCC4=CC=C(Cl)C=C4)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mantell S, Jones R, Trevethick M. Design and application of locally delivered agonists of the adenosine A(2A) receptor. Expert Rev Clin Pharmacol. 2010 Jan;3(1):55-72. doi: 10.1586/ecp.09.57. PubMed PMID: 22111533. 2: Desai A, Victor-Vega C, Gadangi S, Montesinos MC, Chu CC, Cronstein BN. Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. Mol Pharmacol. 2005 May;67(5):1406-13. Epub 2005 Jan 26. PubMed PMID: 15673602. 3: Reiss AB, Rahman MM, Chan ES, Montesinos MC, Awadallah NW, Cronstein BN. Adenosine A2A receptor occupancy stimulates expression of proteins involved in reverse cholesterol transport and inhibits foam cell formation in macrophages. J Leukoc Biol. 2004 Sep;76(3):727-34. Epub 2004 Jun 14. PubMed PMID: 15197231. 4: Nguyen DK, Montesinos MC, Williams AJ, Kelly M, Cronstein BN. Th1 cytokines regulate adenosine receptors and their downstream signaling elements in human microvascular endothelial cells. J Immunol. 2003 Oct 15;171(8):3991-8. PubMed PMID: 14530318. 5: Victor-Vega C, Desai A, Montesinos MC, Cronstein BN. Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel). Inflammation. 2002 Feb;26(1):19-24. PubMed PMID: 11936752.