Filibuvir | PF00868554 | CAS#877130-28-4 | NS5B inhibitor

MedKoo Cat#: 319827 | Name: Filibuvir

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Filibuvir, also known as PF00868554, is a non-nucleoside orally available NS5B inhibitor under development for the treatment of hepatitis C. It binds to the non-catalytic Thumb II allosteric pocket of NS5B viral polymerase and causes a decrease in viral RNA synthesis. It is a potent and selective inhibitor, with a mean IC50 of 0.019 μM against genotype 1 polymerases. Its investigation was discontinued on February 2013 due to strategic reasons.

Chemical Structure

Filibuvir

CAS#877130-28-4

Theoretical Analysis

MedKoo Cat#: 319827

Name: Filibuvir

CAS#: 877130-28-4

Chemical Formula: C29H37N5O3

Exact Mass: 503.2896

Molecular Weight: 503.65

Elemental Analysis: C, 69.16; H, 7.41; N, 13.91; O, 9.53

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	Back order
25mg	USD 950.00	Back order

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Related CAS #

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Synonym

PF00868554; PF-00868554; PF 00868554; PF868554; PF-868554; PF 868554; Filibuvir

IUPAC/Chemical Name

(R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydro-2H-pyran-2-one

InChi Key

SLVAPEZTBDBAPI-GDLZYMKVSA-N

InChi Code

InChI=1S/C29H37N5O3/c1-5-22-14-20(15-23(6-2)31-22)11-12-29(21-9-7-8-10-21)17-25(35)24(27(36)37-29)16-26-32-28-30-18(3)13-19(4)34(28)33-26/h13-15,21,35H,5-12,16-17H2,1-4H3/t29-/m1/s1

SMILES Code

O=C1C(CC2=NN3C(C)=CC(C)=NC3=N2)=C(O)C[C@](CCC4=CC(CC)=NC(CC)=C4)(C5CCCC5)O1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Certificate of Analysis

View CoA: current batch, Lot#S9G04M13

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 503.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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