Afacifenacin, also known as NS-986 and SMP-986, is a muscarinic receptor antagonist. Afacifenacin possesses the dual pharmacological actions of muscarinic receptor antagonism (non-selective) and inhibition of the bladder afferent pathway through Na+-channel blockade. Afacifenacin is being evaluated for its ability to ease urinary urgency and reduce the frequency of both urination and incontinence. Afacifenacin has also exhibited the potential to have lower incidence of side effects related to muscarinic receptor antagonism, such as dry mouth.
MedKoo Cat#: 319818
Name: Afacifenacin fumarate
CAS#: 877606-63-8 (fumarate); 877606-63-8 (free base).
Chemical Formula: C31H30F3N3O6
Exact Mass:
Molecular Weight: 597.59
Elemental Analysis: C, 62.31; H, 5.06; F, 9.54; N, 7.03; O, 16.06
The following data is based on the product molecular weight 597.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
