MedKoo Cat#: 317892 | Name: Flupenthixol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flupentixol is a typical antipsychotic drug of the thioxanthene class. Flupentixol's main use is as a long-acting injection given once in every two or three weeks to individuals with schizophrenia who have poor compliance with medication and suffer frequent relapses of illness. Flupentixol is also used in low doses as an antidepressant. There is tentative evidence that it reduces the rate of deliberate self-harm, among those who self harm repeatedly.

Chemical Structure

Flupenthixol
Flupenthixol
CAS#2709-56-0

Theoretical Analysis

MedKoo Cat#: 317892

Name: Flupenthixol

CAS#: 2709-56-0

Chemical Formula: C23H25F3N2OS

Exact Mass: 434.1640

Molecular Weight: 434.52

Elemental Analysis: C, 63.58; H, 5.80; F, 13.12; N, 6.45; O, 3.68; S, 7.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Flupenthixol, Flupenthixol, Depixol, Fluanxol, Emergil, Siplaril
IUPAC/Chemical Name
2-[4-[(3Z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol
InChi Key
NJMYODHXAKYRHW-DVZOWYKESA-N
InChi Code
InChI=1S/C23H25F3N2OS/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29/h1-2,4-8,16,29H,3,9-15H2/b18-5-
SMILES Code
FC(C1=CC(/C2=C\CCN3CCN(CCO)CC3)=C(SC4=C2C=CC=C4)C=C1)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 434.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tardy M, Dold M, Engel RR, Leucht S. Flupenthixol versus low-potency first-generation antipsychotic drugs for schizophrenia. Cochrane Database Syst Rev. 2014 Sep 1;9:CD009227. doi: 10.1002/14651858.CD009227.pub2. Review. PubMed PMID: 25177834. 2: Mahapatra J, Quraishi SN, David A, Sampson S, Adams CE. Flupenthixol decanoate (depot) for schizophrenia or other similar psychotic disorders. Cochrane Database Syst Rev. 2014 Jun 10;6:CD001470. doi: 10.1002/14651858.CD001470.pub2. Review. PubMed PMID: 24915451. 3: Shen X, Xia J, Adams CE. Flupenthixol versus placebo for schizophrenia. Cochrane Database Syst Rev. 2012 Nov 14;11:CD009777. doi: 10.1002/14651858.CD009777.pub2. Review. PubMed PMID: 23152280. 4: Soyka M, De Vry J. Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence. Eur Neuropsychopharmacol. 2000 Sep;10(5):325-32. Review. PubMed PMID0974602. 5: Kühn KU, Meyer K, Maier W. [Flupenthixol--a partial atypical neuroleptic?]. Fortschr Neurol Psychiatr. 2000 Apr;68 Suppl 1:S38-41. Review. German. PubMed PMID: 10907612. 6: Quraishi S, David A. Depot flupenthixol decanoate for schizophrenia or other similar psychotic disorders. Cochrane Database Syst Rev. 2000;(2):CD001470. Review. Update in: Cochrane Database Syst Rev. 2014;6:CD001470. PubMed PMID: 10796442. 7: Gruber AJ, Cole JO. Antidepressant effects of flupenthixol. Pharmacotherapy. 1991;11(6):450-9. Review. PubMed PMID: 1771144.