Cefixime | CAS#79350-37-1 | Cephalosporin Antibiotic

MedKoo Cat#: 317387 | Name: Cefixime

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cefixime is a third generation cephalosporin antibiotic. It is effective against a variety of Gram-negative bacteria, including E. coli, K. pneumoniae, and H. influenzae. Cefixime binds penicillin-binding proteins and is stable to many penicillinases and β-lactamases. It is an effective, orally-active cephalosporin with applications in acute otitis media, respiratory tract infections, and urinary tract infections.

Chemical Structure

Cefixime

CAS#79350-37-1

Theoretical Analysis

MedKoo Cat#: 317387

Name: Cefixime

CAS#: 79350-37-1

Chemical Formula: C16H15N5O7S2

Exact Mass: 453.0413

Molecular Weight: 453.45

Elemental Analysis: C, 42.38; H, 3.33; N, 15.44; O, 24.70; S, 14.14

Price and Availability

Size	Price	Availability
1g	USD 350.00	2 Weeks
5g	USD 750.00	2 Weeks
10g	USD 1,250.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Cefixime; Cefixim; Cefixoral; Unixime; Cefiximum; Cefixima; FR17027; Suprax; Trihydrate, Cefixime; FK 027; FK-027; FK027; FR 17027; FR-17027;

IUPAC/Chemical Name

(6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

InChi Key

OKBVVJOGVLARMR-VINNURBNSA-N

InChi Code

InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9+/t10-,14-/m1/s1

SMILES Code

C=CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N/OCC(=O)O)/C3=CSC(=N3)N)SC1)C(=O)O

Appearance

Off-white to slightly yellow solid powder.

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 453.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pistiki A, Tsaganos T, Galani I, Giamarellos-Bourboulis EJ. In Vitro Activity of Oral Cephalosporins (Cefprozil and Cefixime) Against Ciprofloxacin-Resistant Enterobacteriaceae from Community-Acquired Urinary-Tract Infections. Infect Dis Ther. 2015 Dec;4(4):425-32. doi: 10.1007/s40121-015-0089-3. Epub 2015 Sep 21. PubMed PMID: 26391612; PubMed Central PMCID: PMC4675762. 2: Shariati-Rad M, Irandoust M, Mohammadi S. Spectrophotometric determination of nitrite in soil and water using cefixime and central composite design. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Oct 5;149:190-5. doi: 10.1016/j.saa.2015.04.083. Epub 2015 May 2. PubMed PMID: 25965167. 3: Zhang L, Liu B, Li Z, Guo Y. Comparative studies on the interaction of cefixime with bovine serum albumin by fluorescence quenching spectroscopy and synchronous fluorescence spectroscopy. Luminescence. 2015 Aug;30(5):686-92. doi: 10.1002/bio.2805. Epub 2014 Oct 29. PubMed PMID: 25351241. 4: Dubala A, Nagarajan JS, Vimal CS, George R. Simultaneous liquid chromatography-mass spectrometry quantification of cefixime and clavulanic acid in human plasma. J Chromatogr Sci. 2015 May-Jun;53(5):694-701. doi: 10.1093/chromsci/bmu106. Epub 2014 Sep 10. PubMed PMID: 25209681. 5: Sirisolla J, Ramanamurthy KV. Formulation and Evaluation of Cefixime Trihydrate Matrix Tablets Using HPMC, Sodium CMC, Ethyl Cellulose. Indian J Pharm Sci. 2015 May-Jun;77(3):321-7. PubMed PMID: 26180278; PubMed Central PMCID: PMC4502147. 6: Mostafa NM, Abdel-Fattah L, Weshahy SA, Hassan NY, Boltia SA. Validated stability-indicating spectrophotometric methods for the determination of cefixime trihydrate in the presence of its acid and alkali degradation products. J AOAC Int. 2015 Jan-Feb;98(1):35-45. doi: 10.5740/jaoacint.14-074. PubMed PMID: 25857876. 7: Istifli ES, Topaktaş M. In vitro genotoxicity and cytotoxicity of a particular combination of pemetrexed and cefixime in human peripheral blood lymphocytes. Springerplus. 2015 Jan 28;4:35. doi: 10.1186/s40064-015-0803-3. eCollection 2015. PubMed PMID: 25653913; PubMed Central PMCID: PMC4312319. 8: Patil SV, Hajare AL, Patankar M, Krishnaprasad K. In Vitro Fractional Inhibitory Concentration (FIC) Study of Cefixime and Azithromycin Fixed Dose Combination (FDC) Against Respiratory Clinical Isolates. J Clin Diagn Res. 2015 Feb;9(2):DC13-5. doi: 10.7860/JCDR/2015/12092.5560. Epub 2015 Feb 1. PubMed PMID: 25859454; PubMed Central PMCID: PMC4378736. 9: Keskar MR, Jugade RM. Spectrophotometric Determination of Cefixime Trihydrate in Pharmaceutical Formulations Based on Ion-Pair Reaction with Bromophenol Blue. Anal Chem Insights. 2015 Jul 27;10:11-6. doi: 10.4137/ACI.S28463. eCollection 2015. PubMed PMID: 26279621; PubMed Central PMCID: PMC4517833. 10: Patel NS, Tandel FB, Patel YD, Thakkar KB. Development and Validation of Stability-indicating HPLC Method for Simultaneous Estimation of Cefixime and Linezolid. Indian J Pharm Sci. 2014 Nov-Dec;76(6):535-40. PubMed PMID: 25593387; PubMed Central PMCID: PMC4293685. 11: Wang L, Wang C, Liu Q, Meng Q, Huo X, Sun P, Yang X, Sun H, Zhen Y, Peng J, Ma X, Liu K. PEPT1- and OAT1/3-mediated drug-drug interactions between bestatin and cefixime in vivo and in vitro in rats, and in vitro in human. Eur J Pharm Sci. 2014 Oct 15;63:77-86. doi: 10.1016/j.ejps.2014.06.019. Epub 2014 Jul 9. PubMed PMID: 25016073. 12: Begum B, Haque MA, Ahmed MS, Islam MN, Ahsan MM, Khan AH, Hasan MM, Akhtaruzzaman M, Hossain MA, Khaleque MA, Choudhury AM, Khatun AA. Comparison between azithromycin and cefixime in the treatment of typhoid fever in children. Mymensingh Med J. 2014 Jul;23(3):441-8. PubMed PMID: 25178594. 13: Thakur SD, Starnino S, Horsman GB, Levett PN, Dillon JR. Unique combined penA/mtrR/porB mutations and NG-MAST strain types associated with ceftriaxone and cefixime MIC increases in a 'susceptible' Neisseria gonorrhoeae population. J Antimicrob Chemother. 2014 Jun;69(6):1510-6. doi: 10.1093/jac/dkt543. Epub 2014 Feb 13. PubMed PMID: 24532681. 14: Quaye N, Cole MJ, Ison CA. Evaluation of the activity of ertapenem against gonococcal isolates exhibiting a range of susceptibilities to cefixime. J Antimicrob Chemother. 2014 Jun;69(6):1568-71. doi: 10.1093/jac/dkt537. Epub 2014 Feb 2. PubMed PMID: 24492260. 15: Grad YH, Kirkcaldy RD, Trees D, Dordel J, Harris SR, Goldstein E, Weinstock H, Parkhill J, Hanage WP, Bentley S, Lipsitch M. Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study. Lancet Infect Dis. 2014 Mar;14(3):220-6. doi: 10.1016/S1473-3099(13)70693-5. Epub 2014 Jan 22. PubMed PMID: 24462211; PubMed Central PMCID: PMC4030102. 16: Bhinge SD, Malipatil SM, Sonawane LV. Bioanalytical method development and validation for simultaneous estimation of cefixime and dicloxacillin by RP-HPLC in human plasma. Acta Chim Slov. 2014;61(3):580-6. PubMed PMID: 25286213. 17: Yu RX, Yin Y, Wang GQ, Chen SC, Zheng BJ, Dai XQ, Han Y, Li Q, Zhang GY, Chen X. Worldwide susceptibility rates of Neisseria gonorrhoeae isolates to cefixime and cefpodoxime: a systematic review and meta-analysis. PLoS One. 2014 Jan 31;9(1):e87849. doi: 10.1371/journal.pone.0087849. eCollection 2014. Review. PubMed PMID: 24498212; PubMed Central PMCID: PMC3909252. 18: Manzoori JL, Amjadi M, Soltani N, Jouyban A. Spectrofluorimetric determination of cefixime using terbium-danofloxacin probe. Iran J Basic Med Sci. 2014;17(4):256-62. PubMed PMID: 24904718; PubMed Central PMCID: PMC4046237. 19: Kovari H, de Melo Oliveira MD, Hauser P, Läuchli S, Meyer J, Weber R, Zbinden R. Decreased susceptibility of Neisseria gonorrhoeae isolates from Switzerland to Cefixime and Ceftriaxone: antimicrobial susceptibility data from 1990 and 2000 to 2012. BMC Infect Dis. 2013 Dec 26;13:603. doi: 10.1186/1471-2334-13-603. PubMed PMID: 24369054; PubMed Central PMCID: PMC3881505. 20: Gose S, Kong CJ, Lee Y, Samuel MC, Bauer HM, Dixon P, Soge OO, Lei J, Pandori M. Comparison of Neisseria gonorrhoeae MICs obtained by Etest and agar dilution for ceftriaxone, cefpodoxime, cefixime and azithromycin. J Microbiol Methods. 2013 Dec;95(3):379-80. PubMed PMID: 24455772.