AZD1979 is a melanin concentrating hormone receptor 1 (MCHr1) antagonist (Ki MCHr1 (GTP7s) = 5.1 nM; Ki MCHr1 (Binding) -12.1 nM). AZD1979 has excellent DMPK properties and gave robust effects on weight loss when dosed orally in a DIO mouse model. Preclinical GLP tox and safety pharmacology studies were without treatment related findings and 103 was selected as a clinical candidate. MCHr1 knockout (KO) mice are resistant to dietary induced obesity (DIO) mainly due to elevated motor activity and energy expenditure. MCHr1 antagonists have been investigated preclinically as a treatment option for obesity, depression and anxiety disorders.
MedKoo Cat#: 522626
Name: AZD1979
CAS#: 1254035-84-1
Chemical Formula: C25H26N4O5
Exact Mass: 462.1903
Molecular Weight: 462.51
Elemental Analysis: C, 64.92; H, 5.67; N, 12.11; O, 17.30
The following data is based on the product molecular weight 462.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
