Vercirnon | GSK1605786 | CCX282-B | CAS#698394-73-9 | 886214-18-2 | CCR9 Antagonist

MedKoo Cat#: 319723 | Name: Vercirnon

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vercirnon, also known as CCX282-B and GSK1605786, is a potent and orally active CCR9 antagonist, which is currently under development for Crohn's disease. CCX282-B inhibited CCR9-mediated Ca(2+) mobilization and chemotaxis on Molt-4 cells with IC(50) values of 5.4 and 3.4 nM, respectively. CCX282-B inhibited CCR9-mediated chemotaxis with an IC(50) of 33 nM. CCX282-B inhibited chemotaxis of primary CCR9-expressing cells to CCL25 with an IC(50) of 6.8 nM. CCX282-B was an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC(50) values of 2.8 and 2.6 nM, respectively. CCX282-B also inhibited mouse and rat CCR9-mediated chemotaxis.

Chemical Structure

Vercirnon

CAS#698394-73-9

Theoretical Analysis

MedKoo Cat#: 319723

Name: Vercirnon

CAS#: 698394-73-9

Chemical Formula: C22H21ClN2O4S

Exact Mass: 444.0911

Molecular Weight: 444.93

Elemental Analysis: C, 59.39; H, 4.76; Cl, 7.97; N, 6.30; O, 14.38; S, 7.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

GSK1605786; GSK 1605786; GSK-1605786; CCX282B; CCX 282B; CCX-282b; CCX282-B; Vercirnon.

IUPAC/Chemical Name

4-(2-((4-(tert-butyl)phenyl)sulfonamido)-5-chlorobenzoyl)pyridine 1-oxide

InChi Key

JRWROCIMSDXGOZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H21ClN2O4S/c1-22(2,3)16-4-7-18(8-5-16)30(28,29)24-20-9-6-17(23)14-19(20)21(26)15-10-12-25(27)13-11-15/h4-14,24H,1-3H3

SMILES Code

O=C(C1=CC=[N+]([O-])C=C1)C2=CC(Cl)=CC=C2NS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# CAS No. 698394-73-9(Vercirnon) 886214-18-2(Vercirnon Sodium) CCR9 antagonism is a promising new therapeutic approach for the treatment of Crohn's disease. CCR9 is expressed on the cell surface of memory/effector CD4(+) T cells and selectively binds to the small intestinal lymphocyte chemoattractant CCL25 (TECK). Blockade of the CCR9/CCL25 interaction inhibits lymphocyte homing to the intestinal mucosa, thereby limiting inflammation and disease at this site.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 444.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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