Asapiprant, also known as S-555739, is a the potent and selective DP1 receptor antagonist. Asapiprant exhibited high affinity and selectivity for the DP1 receptor. Significant suppression of antigen-induced nasal resistance, nasal secretion, and cell infiltration in nasal mucosa was observed with asapiprant treatment. In addition, treatment with asapiprant suppressed antigen-induced asthmatic responses, airway hyper-responsiveness, and cell infiltration and mucin production in lung. These results show that asapiprant is a potent and selective DP1 receptor antagonist, and exerts suppressive effects in the animal models of allergic diseases. Thus, asapiprant has potential as a novel therapy for allergic airway diseases.
MedKoo Cat#: 319665
Name: Asapiprant
CAS#: 932372-01-5
Chemical Formula: C24H27N3O7S
Exact Mass: 501.1570
Molecular Weight: 501.55
Elemental Analysis: C, 57.47; H, 5.43; N, 8.38; O, 22.33; S, 6.39
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.1 | 14.08 | |
| DMF | 10.0 | 19.94 | |
| DMF:PBS (pH 7.2) (1:5) | 0.2 | 0.32 |
The following data is based on the product molecular weight 501.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
