IUPAC/Chemical Name
1-(2-(2,4-dichlorophenyl)-2-((4-(trifluoromethyl)benzyl)oxy)ethyl)-1H-imidazole
InChi Key
FUAHXHWSMYFWGE-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H15Cl2F3N2O/c20-15-5-6-16(17(21)9-15)18(10-26-8-7-25-12-26)27-11-13-1-3-14(4-2-13)19(22,23)24/h1-9,12,18H,10-11H2
SMILES Code
FC(C1=CC=C(COC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)C=C1)(F)F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Dapaconazole, as an antifungal agent, inhibits sterol 14α-demethylase cytochrome P450 activity with an IC50 of 1.4 μM
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
100.0 |
240.82 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
415.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message
Sent On: Tue Sep 12 12:59:27 2023
Search: Dapaconazole
From: benjamin.healy@medkoo.com
6 selected items
PubMed Results
Items 1-6 of 6 (Display the 6 citations in PubMed)
1: Antunes NJ, Moreira FL, Kipper K, Couchman L, Lebre DT, Johnston A, De Nucci G. Prospective Prediction of Dapaconazole Clinical Drug-Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling. Pharmaceuticals (Basel). 2022 Dec 26;16(1):28. doi: 10.3390/ph16010028. PMID: 36678526; PMCID: PMC9861162.
2: Antunes NJ, Coombes G, da Cunha KF, Moreira FL, Pilon AC, Lopes NP, Costa JLD, Kipper K, Couchman L, Johnston A, De Nucci G. In vitro metabolism of the new antifungal dapaconazole using liver microsomes. Drug Metab Pharmacokinet. 2022 Dec;47:100475. doi: 10.1016/j.dmpk.2022.100475. Epub 2022 Sep 20. PMID: 36370616.
3: Gobbato AAM, Babadópulos T, Gobbato CARS, Ilha JO, Antunes NJ, Moreno RA, Campos R, De Nucci G. Comparison of dapaconazole with miconazole in the treatment of Tinea cruris. J Eur Acad Dermatol Venereol. 2019 Jan;33(1):e18-e20. doi: 10.1111/jdv.15116. Epub 2018 Jul 6. PMID: 29888509.
4: Gobbato AAM, Gobbato CARS, Moreno RA, Antunes NJ, De Nucci G. Dapaconazole versus ketoconazole in the treatment of interdigital tinea pedis. Int J Clin Pharmacol Ther. 2018 Jan;56(1):31-33. doi: 10.5414/CP203124. PMID: 29191265.
5: Gobbato AA, Babadópulos T, Gobbato CA, Ilha Jde O, Gagliano-Jucá T, De Nucci G. A randomized double-blind, non-inferiority Phase II trial, comparing dapaconazole tosylate 2% cream with ketoconazole 2% cream in the treatment of Pityriasis versicolor. Expert Opin Investig Drugs. 2015;24(11):1399-407. doi: 10.1517/13543784.2015.1083009. Epub 2015 Sep 30. PMID: 26419668.
6: de Moraes FC, Bittencourt SF, Perissutti E, Frencentese F, Arruda AM, Chen LS, Babadópulos T, De Nucci G. Quantification of dapaconazole in human plasma using high-performance liquid chromatography coupled to tandem mass spectrometry: application to a phase I study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 1;958:102-7. doi: 10.1016/j.jchromb.2014.01.053. Epub 2014 Mar 12. PMID: 24705538.
