Synonym
Flucytosine; Flucytosin; Fluorocytosine; 5-fluorocytosine; 5-FC; Ancobon; Ancotil; NSC 103805; NSC103805; NSC-103805; Ro-29915; Ro 2-9915; Ro-2-9915
IUPAC/Chemical Name
6-amino-5-fluoro-1H-pyrimidin-2-one
InChi Key
XRECTZIEBJDKEO-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
SMILES Code
O=C1N=CC(F)=C(N)N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
129.09
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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6: Heidemann H. Prevention of amphotericin B nephrotoxicity: the effect of salt loading and flucytosine. Mycoses. 1988;31 Suppl 2:39-44. Review. PubMed PMID: 3067090.
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8: Bennet JE. Flucytosine. Ann Intern Med. 1977 Mar;86(3):319-21. Review. PubMed PMID: 320931.
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10: Vermes A, Guchelaar HJ, Dankert J. Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother. 2000 Aug;46(2):171-9. Review. PubMed PMID: 10933638.
11: Viviani MA. Flucytosine--what is its future? J Antimicrob Chemother. 1995 Feb;35(2):241-4. Review. PubMed PMID: 7759388.
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13: Paladino JA, Crass RE. Amphotericin B and flucytosine in the treatment of candidal cystitis. Clin Pharm. 1982 Jul-Aug;1(4):349-52. Review. PubMed PMID: 6764395.
