Synonym
AMG-369; AMG 369; AMG369; KB-74649; KB74649; KB 74649.
IUPAC/Chemical Name
1-(3-fluoro-4-(6-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzyl)azetidine-3-carboxylic acid
InChi Key
DSAOIEDPZKHAOM-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H22FN3O2S/c27-21-10-16(13-30-14-17(15-30)25(31)32)6-7-20(21)23-29-22-11-19(12-28-24(22)33-23)26(8-9-26)18-4-2-1-3-5-18/h1-7,10-12,17H,8-9,13-15H2,(H,31,32)
SMILES Code
O=C(C1CN(CC2=CC=C(C3=NC4=CC(C5(C6=CC=CC=C6)CC5)=CN=C4S3)C(F)=C2)C1)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
459.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Victor J. Cee*†, Mike Frohn†, Brian A. Lanman†, Jennifer Golden†, Kristine Muller†, Susana Neira†, Alex Pickrell†, Heather Arnett‡, Janet Buys†, Anu Gore†, Mike Fiorino†, Michelle Horner†, Andrea Itano†, Matt R. Lee†, Michele McElvain†, Scot Middleton†, Michael Schrag†, Dalia Rivenzon-Segal§, Hugo M. Vargas†, Han Xu†, Yang Xu†, Xuxia Zhang†, Jerry Siu†, Min Wong†, and Roland W. Bürli. Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5. ACS Med. Chem. Lett., 2011, 2 (2), pp 107–112
