Senexin A is a potent and selective CDK8 inhibitor (IC50 = 280 nM). Senexin A binds to cdk19 in an ATP-competitive manner. Senexin A inhibits p21-induced transcription. Senexin A may exert the effects against the activation of tumor-promoting and pro-inflammatory secreted factors in the tumor microenvironment by preventing transcriptional activation of NFκB-induced genes.
MedKoo Cat#: 407249
Name: Senexin A
CAS#: 1366002-50-7
Chemical Formula: C17H14N4
Exact Mass: 274.1218
Molecular Weight: 274.33
Elemental Analysis: C, 74.43; H, 5.14; N, 20.42
The following data is based on the product molecular weight 274.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
