MedKoo Cat#: 317876 | Name: Fleroxacin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fleroxacin, a quinolone, is a bactericidal drug that inhibits bacterial DNA gyrase and topoisomerase IV. Like other quinolones and fluoroquinolones the compound eradicates bacteria by interfering with DNA replication (bacterial DNA replication, transcription, repair and recombination). Fleroxacin is active against many Gram-positive and Gram-negative bacteria.

Chemical Structure

Fleroxacin
Fleroxacin
CAS#79660-72-3

Theoretical Analysis

MedKoo Cat#: 317876

Name: Fleroxacin

CAS#: 79660-72-3

Chemical Formula: C17H18F3N3O3

Exact Mass: 369.1300

Molecular Weight: 369.34

Elemental Analysis: C, 55.28; H, 4.91; F, 15.43; N, 11.38; O, 13.00

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
2g USD 400.00 2 Weeks
5g USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Fleroxacin; Fleroxicin; Quinodis; Megalocin; Megalone; AM-833; AM833; AM 833; Ro 236240; Ro236240; Ro-236240; Ro 23-6240; Ro23-6240;
IUPAC/Chemical Name
6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
InChi Key
XBJBPGROQZJDOJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
SMILES Code
O=C(C1=CN(CCF)C2=C(C=C(F)C(N3CCN(C)CC3)=C2F)C1=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 369.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kostić D. [Fleroxacin--a new quinolone antibiotic]. Vojnosanit Pregl. 1996 Jul-Aug;53(4):311-24. Review. Serbian. PubMed PMID: 9229948. 2: Neu HC, Chin NX. In vitro activity of fleroxacin in combination with other antimicrobial agents. Am J Med. 1993 Mar 22;94(3A):9S-16S. Review. PubMed PMID: 8452190. 3: Nightingale CH. Overview of the pharmacokinetics of fleroxacin. Am J Med. 1993 Mar 22;94(3A):38S-43S. Review. PubMed PMID: 8452184. 4: Gasser TC, Wisard M, Frei R. Oral fleroxacin prophylaxis in transurethral surgery. J Urol. 1996 Jul;156(1):146-8. Review. PubMed PMID: 8648777. 5: Giamarellou H. Fleroxacin in complicated urinary tract infections. Chemotherapy. 1996 Mar;42 Suppl 1:17-27. Review. PubMed PMID: 8861531. 6: Naber KG. Fleroxacin overview. Chemotherapy. 1996 Mar;42 Suppl 1:1-9. Review. PubMed PMID: 8861529. 7: Balfour JA, Todd PA, Peters DH. Fleroxacin. A review of its pharmacology and therapeutic efficacy in various infections. Drugs. 1995 May;49(5):794-850. Review. PubMed PMID: 7601015. 8: Niwicka A. [Fleroxacin--spectrum of activity, pharmacokinetics and clinical use]. Pol Tyg Lek. 1993 Dec 13-27;48(50-52):864-6. Review. Polish. PubMed PMID: 7971511. 9: Stuck AE, Kim DK, Frey FJ. Fleroxacin clinical pharmacokinetics. Clin Pharmacokinet. 1992 Feb;22(2):116-31. Review. PubMed PMID: 1551289.