Synonym
PF-06260414; PF 06260414; PF06260414; PF6260414; PF-6260414; PF 6260414.
IUPAC/Chemical Name
(R)-6-(4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl)isoquinoline-1-carbonitrile
InChi Key
ZKAVFOXYJCREBQ-SNVBAGLBSA-N
InChi Code
InChI=1S/C14H14N4O2S/c1-10-8-17-21(19,20)18(9-10)12-2-3-13-11(6-12)4-5-16-14(13)7-15/h2-6,10,17H,8-9H2,1H3/t10-/m1/s1
SMILES Code
N#CC1=NC=CC2=C1C=CC(N(C[C@H](C)CN3)S3(=O)=O)=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
PF-06260414 is a selective androgen receptor modulator, or SARM.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
302.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P. Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes. Drug Test Anal. 2022 Feb;14(2):349-370. doi: 10.1002/dta.3189. Epub 2021 Dec 10. PMID: 34714606.
2: Ventura E, Gadaj A, Buckley T, Mooney MH. Development of a multi-residue high-throughput UHPLC-MS/MS method for routine monitoring of SARM compounds in equine and bovine blood. Drug Test Anal. 2020 Sep;12(9):1373-1379. doi: 10.1002/dta.2875. Epub 2020 Jun 24. PMID: 32519780.
3: Ventura E, Gadaj A, Buckley T, Mooney MH. Investigation of stability of selective androgen receptor modulators in urine. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020 Aug;37(8):1253-1263. doi: 10.1080/19440049.2020.1757165. Epub 2020 May 13. PMID: 32401172.
4: Thevis M, Volmer DA. Mass spectrometric studies on selective androgen receptor modulators (SARMs) using electron ionization and electrospray ionization/collision-induced dissociation. Eur J Mass Spectrom (Chichester). 2018 Feb;24(1):145-156. doi: 10.1177/1469066717731228. Epub 2017 Sep 13. PMID: 29232975.
5: Bhattacharya I, Tarabar S, Liang Y, Pradhan V, Owens J, Oemar B. Safety, Pharmacokinetic, and Pharmacodynamic Evaluation After Single and Multiple Ascending Doses of a Novel Selective Androgen Receptor Modulator in Healthy Subjects. Clin Ther. 2016 Jun;38(6):1401-1416. doi: 10.1016/j.clinthera.2016.03.025. Epub 2016 Apr 13. PMID: 27085586.
