SMDC818909 is a potent and selective p97 inhibitor. The IC50 value of SMDC818909 decreased with increasing ATP concentration (26.0 ± 0.9, 11.5 ± 0.9, and 4.9 ± 0.9 μM at 5, 20, and 100 μM ATP, respectively), indicating that it behaved primarily uncompetitively with the ATP substrate. SMDC818909 represents a novel uncompetitive inhibitor with excellent physical and pharmaceutical properties that can be used as a starting point for drug discovery efforts.
MedKoo Cat#: 407242
Name: SMDC818909
CAS#: 1147823-21-9
Chemical Formula: C14H13N5O
Exact Mass: 267.1120
Molecular Weight: 267.29
Elemental Analysis: C, 62.91; H, 4.90; N, 26.20; O, 5.99
The following data is based on the product molecular weight 267.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
