Diethylstilbestrol | CAS#56-53-1

MedKoo Cat#: 317610 | Name: Diethylstilbestrol

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diethylstilbestrol is a synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration. (Source: https://en.wikipedia.org/wiki/Diethylstilbestrol).

Chemical Structure

Diethylstilbestrol

CAS#56-53-1

Theoretical Analysis

MedKoo Cat#: 317610

Name: Diethylstilbestrol

CAS#: 56-53-1

Chemical Formula: C18H20O2

Exact Mass: 268.1463

Molecular Weight: 268.35

Elemental Analysis: C, 80.56; H, 7.51; O, 11.92

Price and Availability

Size	Price	Availability	Quantity
1g	USD 250.00	2 weeks
5g	USD 550.00	2 weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Diethylstilbestrol; Stilbestrol; Stilboestrol; Distilbene; Stilboestroform;

IUPAC/Chemical Name

4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol

InChi Key

RGLYKWWBQGJZGM-ISLYRVAYSA-N

InChi Code

InChI=1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+

SMILES Code

CC/C(=C(/CC)\C1=CC=C(C=C1)O)/C2=CC=C(C=C2)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 268.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: He X, Mei X, Wang J, Lian Z, Tan L, Wu W. Determination of diethylstilbestrol in seawater by molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography. Mar Pollut Bull. 2015 Nov 29. pii: S0025-326X(15)30191-0. doi: 10.1016/j.marpolbul.2015.11.041. [Epub ahead of print] PubMed PMID: 26646976. 2: Yin L, Zheng LJ, Jiang X, Liu WB, Han F, Cao J, Liu JY. Effects of Low-Dose Diethylstilbestrol Exposure on DNA Methylation in Mouse Spermatocytes. PLoS One. 2015 Nov 20;10(11):e0143143. doi: 10.1371/journal.pone.0143143. eCollection 2015. PubMed PMID: 26588706; PubMed Central PMCID: PMC4654501. 3: Li X, Ling WT, Liu JX, Sun MX, Gao YZ, Liu J. [Immobilization of Estrogen-degrading Bacteria to Remove the 17β-estradiol and Diethylstilbestrol from Polluted Water and Cow Dung]. Huan Jing Ke Xue. 2015 Jul;36(7):2581-90. Chinese. PubMed PMID: 26489328. 4: Tatsumi K, Schlappe B, Everett EN, Gibson PC, Mount SL. Primary Vaginal Mucinous Adenocarcinoma of Intestinal Type, Associated With Intestinal Metaplasia of Skene Ducts in a Diethylstilbestrol-Exposed Woman. Am J Clin Pathol. 2015 Nov;144(5):790-5. doi: 10.1309/AJCPVZ0QNLUO7OFE. PubMed PMID: 26486744. 5: Yin Y, Lin C, Zhang I, Fisher AV, Dhandha M, Ma L. Homeodomain Transcription Factor Msx-2 Regulates Uterine Progenitor Cell Response to Diethylstilbestrol. J Stem Cell Transplant Biol. 2015;1(1). pii: 105. Epub 2015 May 12. PubMed PMID: 26457333; PubMed Central PMCID: PMC4596533. 6: Hodnik Ž, Tomašič T, Smodiš D, D'Amore C, Mašič LP, Fiorucci S, Kikelj D. Diethylstilbestrol-scaffold-based pregnane X receptor modulators. Eur J Med Chem. 2015 Oct 20;103:551-62. doi: 10.1016/j.ejmech.2015.09.005. Epub 2015 Sep 8. PubMed PMID: 26408814. 7: Herbst AL, Anderson D. Diethylstilbestrol (DES) Pregnancy Treatment: A Promising Widely Used Therapy with Unintended Adverse Consequences. AMA J Ethics. 2015 Sep 1;17(9):865-70. doi: 10.1001/journalofethics.2015.17.9.mhst1-1509. PubMed PMID: 26390210. 8: Haeno S, Maeda N, Yamaguchi K, Sato M, Uto A, Yokota H. Adrenal steroidogenesis disruption caused by HDL/cholesterol suppression in diethylstilbestrol-treated adult male rat. Endocrine. 2015 Sep 8. [Epub ahead of print] PubMed PMID: 26349937. 9: Zhang X, Ke S, Chen KH, Li JH, Ma L, Jiang XW. Diethylstilbestrol affects the expression of GPER in the gubernaculum testis. Int J Clin Exp Pathol. 2015 Jun 1;8(6):7217-22. eCollection 2015. PubMed PMID: 26261617; PubMed Central PMCID: PMC4525951. 10: Tang J, Li Q, Cheng B, Huang C, Chen K. Effects of diethylstilbestrol on the proliferation and tyrosinase activity of cultured human melanocytes. Biomed Rep. 2015 Jul;3(4):499-502. Epub 2015 May 27. PubMed PMID: 26171155; PubMed Central PMCID: PMC4487004.