Synonym
Dichlorphenamide; Diclofenamide; Diclofenamid; Daranide; Dichlorphenamide; Oratrol
IUPAC/Chemical Name
4,5-dichlorobenzene-1,3-disulfonamide
InChi Key
GJQPMPFPNINLKP-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)
SMILES Code
C1=C(C=C(C(=C1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
305.16
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tawil R, McDermott MP, Brown R Jr, Shapiro BC, Ptacek LJ, McManis PG, Dalakas MC, Spector SA, Mendell JR, Hahn AF, Griggs RC. Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis. Ann Neurol. 2000 Jan;47(1):46-53. PubMed PMID: 10632100.
2: Lotti VJ, Schmitt CJ, Gautheron PD. Topical ocular hypotensive activity and ocular penetration of dichlorphenamide sodium in rabbits. Graefes Arch Clin Exp Ophthalmol. 1984;222(1):13-9. PubMed PMID: 6510719.
3: Kishida K, Manabe R. The role of the hydrophobicity of the substituted groups of dichlorphenamide in the development of carbonic anhydrase inhibition. Med J Osaka Univ. 1980 Mar;30(3-4):95-100. PubMed PMID: 7412695.
4: Schmitt C, Vandenheuvel WJ, Walker RW, Plazonnet B. Electron-capture GLC assay of dichlorphenamide. J Pharm Sci. 1979 Mar;68(3):381-3. PubMed PMID: 423137.
5: Bleckmann H. [Dichlorphenamide treatment in acute glaucoma (author's transl)]. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1976 Nov 18;201(1):69-77. German. PubMed PMID: 793439.
6: Lane DJ, Howell JB, Stretton TB. The effect of dichlorphenamide on blood and cerebrospinal fluid acid-base state in chronic ventilatory failure. Clin Sci. 1970 Sep;39(3):391-406. PubMed PMID: 5459167.
7: Tota G, Cavallacci G. [Modification of ERG produced by dichlorphenamide]. Ann Ottalmol Clin Ocul. 1970 Jun;96(6):303-11. Italian. PubMed PMID: 5513801.
8: Chiesa A, Stretton TB, Massoud AA, Howell JB. The effects of inhibition of carbonic anhydrase with dichlorphenamide on ventilatory control at rest and on exercise in normal subjects. Clin Sci. 1969 Dec;37(3):689-706. PubMed PMID: 4983199.
9: Constant MA. Distribution of 5,5-dimethyl-2,4-oxazolidinedione (DMO) in intraocular fluids. V. Effect of plasma level, probenecid, and dichlorphenamide on time course. Invest Ophthalmol. 1968 Jun;7(3):334-46. PubMed PMID: 5655878.
10: Chiesa AG, Balbi L, Ciappi G, Zardini P. [Reversibility in vitro and in vivo of carbonic anhydrase inhibition with dichlorphenamide]. Minerva Med. 1966 Oct 27;57(86):3539-42. Italian. PubMed PMID: 4958930.
