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MedKoo Cat#: 317651 | Name: Desloratadine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desloratadine is a tricyclic H1-antihistamine that is used to treat allergies. It is an active metabolite of loratadine. Desloratadine is a selective H1-antihistamine which functions as an inverse agonist at the histamine H1 receptor; it is also an antagonist at all subtypes of the muscarinic acetylcholine receptors. It has a long-lasting effect and in moderate and low doses. It exhibits only peripheral activity since it does not readily cross the blood-brain barrier; hence, it does not cause drowsiness because it does not readily enter the central nervous system. (Source: https://en.wikipedia.org/wiki/Desloratadine).

Chemical Structure

Desloratadine
Desloratadine
CAS#100643-71-8

Theoretical Analysis

MedKoo Cat#: 317651

Name: Desloratadine

CAS#: 100643-71-8

Chemical Formula: C19H19ClN2

Exact Mass: 310.1237

Molecular Weight: 310.82

Elemental Analysis: C, 73.42; H, 6.16; Cl, 11.41; N, 9.01

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 weeks
10g USD 450.00 2 weeks
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Related CAS #
No Data
Synonym
Desloratadine; Desloratidine; Clarinex; Neoclarityn; Descarboethoxyloratadine; Aerius; NSC 675447; NSC675447; NSC-675447; SCH 34117; SCH34117; SCH-34117
IUPAC/Chemical Name
8-chloro-6,11-dihydro-11-(4-piperdinylidene)- 5h-benzo[5,6]cyclohepta[1,2-b]pyridine
InChi Key
JAUOIFJMECXRGI-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
SMILES Code
C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 310.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang K, Zhang XQ, Lu W, Xie HR, He L, Jiang XH, Wang L. [Determination of Desloratadine and Its Metabolite 3-OH Desloratadine in Human Plasma by LC-MS/MS]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Sep;46(5):783-7, 804. Chinese. PubMed PMID: 26619557. 2: Ali AK. Torsade De Pointes And Qt Prolongation Could Result From Desloratadine Anti-Allergy Treatment. Value Health. 2015 Nov;18(7):A493-4. doi: 10.1016/j.jval.2015.09.1376. Epub 2015 Oct 20. PubMed PMID: 26532767. 3: Chen M, Xu S, Zhou P, He G, Jie Q, Wu Y. Desloratadine citrate disodium injection, a potent histamine H1 receptor antagonist, inhibits chemokine production in ovalbumin-induced allergic rhinitis guinea pig model and histamine-induced human nasal epithelial cells via inhibiting the ERK1/2 and NF-kappa B signal cascades. Eur J Pharmacol. 2015 Nov 15;767:98-107. doi: 10.1016/j.ejphar.2015.10.014. Epub 2015 Oct 9. PubMed PMID: 26455479. 4: Wang T, Zhang K, Li T, He L, Xie H, Jiang X, Wang L. Prevalence of Desloratadine Slow-metabolizer Phenotype and Food-dependent Pharmacokinetics of Desloratadine in Healthy Chinese Volunteers. Clin Drug Investig. 2015 Dec;35(12):807-13. doi: 10.1007/s40261-015-0343-1. PubMed PMID: 26446005. 5: Potter P, Mitha E, Barkai L, Gyorgyl M, Santamaria E, Izquierdo I, Maurer M. Rupatadine effective in the treatment of chronic spontaneous urticaria in children aged 2-11 years: a randomized, double blind, placebo and desloratadine controlled study. Pediatr Allergy Immunol. 2015 Aug 12. doi: 10.1111/pai.12460. [Epub ahead of print] PubMed PMID: 26267219. 6: Tatar A, Parlak SN, Yayla M, Ugan RA, Polat E, Halici Z. Effects of allergic rhinitis and desloratadine on the submandibular gland in a rat allergy model. Int Forum Allergy Rhinol. 2015 Jul 22. doi: 10.1002/alr.21589. [Epub ahead of print] PubMed PMID: 26201305. 7: Yuan X, Ghosh A, Jie Q, He G, Wu Y. Effects of desloratadine citrate disodium injection on rat models of ovalbumin-induced allergic rhinitis: involvement of T-cell responses modulation. Int Forum Allergy Rhinol. 2015 Jul 8. doi: 10.1002/alr.21594. [Epub ahead of print] PubMed PMID: 26155922. 8: Kazmi F, Yerino P, Barbara JE, Parkinson A. Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor. Drug Metab Dispos. 2015 Sep;43(9):1294-302. doi: 10.1124/dmd.115.065011. Epub 2015 Jul 1. PubMed PMID: 26135009. 9: Jie Q, Kodithuwakku ND, Yuan X, He G, Chen M, Xu S, Wu Y. Anti-allergic and anti-inflammatory properties of a potent histamine H1 receptor antagonist, desloratadine citrate disodium injection, and its anti-inflammatory mechanism on EA.hy926 endothelial cells. Eur J Pharmacol. 2015 May 5;754:1-10. doi: 10.1016/j.ejphar.2015.02.016. Epub 2015 Feb 19. PubMed PMID: 25704613. 10: Kazmi F, Barbara JE, Yerino P, Parkinson A. A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement. Drug Metab Dispos. 2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620. Epub 2015 Jan 16. PubMed PMID: 25595597.

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