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MedKoo Cat#: 317522 | Name: Cholecalciferol
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cholecalciferol is one of the five forms of vitamin D. It is a secosteroid, a steroid molecule with one ring open. Cholecalciferol is a steroid hormone produced in the skin when exposed to ultraviolet light or obtained from dietary sources. The active form of cholecalciferol, 1,25-dihydroxycholecalciferol plays an important role in maintaining blood calcium and phosphorus levels and mineralization of bone. The activated form of cholecalciferol binds to vitamin D receptors and modulates gene expression.

Chemical Structure

Cholecalciferol
Cholecalciferol
CAS#67-97-0

Theoretical Analysis

MedKoo Cat#: 317522

Name: Cholecalciferol

CAS#: 67-97-0

Chemical Formula: C27H44O

Exact Mass: 384.3392

Molecular Weight: 384.65

Elemental Analysis: C, 84.31; H, 11.53; O, 4.16

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 650.00 2 Weeks
10g USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Cholecalciferol; Vitamin D3; Calciol; Colecalciferol; Arachitol; Activated 7-dehydrocholesterol; Ricketon; Trivitan; Vigantol; Vigorsan; Deparal;
IUPAC/Chemical Name
(S,Z)-3-(2-((1R,3aS,7aR,E)-7a-methyl-1-((R)-6-methylheptan-2-yl)octahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol
InChi Key
QYSXJUFSXHHAJI-YRZJJWOYSA-N
InChi Code
InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
SMILES Code
C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](CCC3=C)O)C
Appearance
White to off-white solid powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in ethanol (30mg/mL), and DMSO (3mg/mL); DMF (20mg/mL)
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot# C21M07C01
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 384.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Treiber G, Prietl B, Fröhlich-Reiterer E, Lechner E, Ribitsch A, Fritsch M, Rami-Merhar B, Steigleder-Schweiger C, Graninger W, Borkenstein M, Pieber TR. Cholecalciferol supplementation improves suppressive capacity of regulatory T-cells in young patients with new-onset type 1 diabetes mellitus - A randomized clinical trial. Clin Immunol. 2015 Dec;161(2):217-24. doi: 10.1016/j.clim.2015.08.002. Epub 2015 Aug 12. PubMed PMID: 26277548. 2: Amrein K, McNally JD, Dobnig H, Pieber TR. High-dose cholecalciferol in critically ill patients with liver cirrhosis. J Intern Med. 2015 Dec 28. doi: 10.1111/joim.12457. [Epub ahead of print] PubMed PMID: 26707009. 3: Kim JH, Kang S, Jung YN, Choi HS. Cholecalciferol inhibits lipid accumulation by regulating early adipogenesis in cultured adipocytes and zebrafish. Biochem Biophys Res Commun. 2015 Dec 17. pii: S0006-291X(15)31057-3. doi: 10.1016/j.bbrc.2015.12.049. [Epub ahead of print] PubMed PMID: 26703207. 4: Aytaç MB, Deveci M, Bek K, Kayabey Ö, Ekinci Z. Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney disease. Pediatr Nephrol. 2016 Feb;31(2):267-77. doi: 10.1007/s00467-015-3220-5. Epub 2015 Oct 2. PubMed PMID: 26432706. 5: Nair P, Venkatesh B, Lee P, Kerr S, Hoechter DJ, Dimeski G, Grice J, Myburgh J, Center JR. A Randomized Study of a Single Dose of Intramuscular Cholecalciferol in Critically Ill Adults. Crit Care Med. 2015 Nov;43(11):2313-20. doi: 10.1097/CCM.0000000000001201. PubMed PMID: 26186566. 6: Gueye Y, Marqueste T, Maurel F, Khrestchatisky M, Decherchi P, Feron F. Cholecalciferol (vitamin D3) improves functional recovery when delivered during the acute phase after a spinal cord trauma. J Steroid Biochem Mol Biol. 2015 Nov;154:23-31. doi: 10.1016/j.jsbmb.2015.06.007. Epub 2015 Jul 6. PubMed PMID: 26159913. 7: Cortes M, Liu SY, Kwan W, Alexa K, Goessling W, North TE. Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation. Stem Cell Reports. 2015 Oct 13;5(4):471-9. doi: 10.1016/j.stemcr.2015.08.010. Epub 2015 Sep 10. PubMed PMID: 26365513; PubMed Central PMCID: PMC4624955. 8: Borowicz KK, Morawska D, Morawska M. Effect of cholecalciferol on the anticonvulsant action of some second generation antiepileptic drugs in the mouse model of maximal electroshock. Pharmacol Rep. 2015 Oct;67(5):875-80. doi: 10.1016/j.pharep.2015.01.012. Epub 2015 Feb 2. PubMed PMID: 26398379. 9: Masood MQ, Khan A, Awan S, Dar F, Naz S, Naureen G, Saghir S, Jabbar A. COMPARISON OF VITAMIN D REPLACEMENT STRATEGIES WITH HIGH-DOSE INTRAMUSCULAR OR ORAL CHOLECALCIFEROL: A PROSPECTIVE INTERVENTION STUDY. Endocr Pract. 2015 Oct;21(10):1125-33. doi: 10.4158/EP15680.OR. Epub 2015 Jul 7. PubMed PMID: 26151421. 10: Kuchay MS, Jevalikar GS, Mithal A, Mishra SK, Dang N. Efficacy and safety of a single monthly dose of cholecalciferol in healthy school children. J Pediatr Endocrinol Metab. 2015 Sep 3. pii: /j/jpem.ahead-of-print/jpem-2015-0187/jpem-2015-0187.xml. doi: 10.1515/jpem-2015-0187. [Epub ahead of print] PubMed PMID: 26353168. 11: Braithwaite MC, Choonara YE, Kumar P, Tomar LK, Du Toit LC, Pillay V. A novel bile salts-lipase polymeric film-infused minitablet system for enhanced oral delivery of cholecalciferol. Pharm Dev Technol. 2015 Sep 3:1-15. [Epub ahead of print] PubMed PMID: 26333524. 12: Quraishi SA, De Pascale G, Needleman JS, Nakazawa H, Kaneki M, Bajwa EK, Camargo CA Jr, Bhan I. Effect of Cholecalciferol Supplementation on Vitamin D Status and Cathelicidin Levels in Sepsis: A Randomized, Placebo-Controlled Trial. Crit Care Med. 2015 Sep;43(9):1928-37. doi: 10.1097/CCM.0000000000001148. PubMed PMID: 26086941; PubMed Central PMCID: PMC4537665. 13: Sahbaz A, Aynioglu O, Isik H, Gulle K, Akpolat Ferah M, Cicekler Sahbaz H. Cholecalciferol (vitamin D3) prevents postoperative adhesion formation by inactivating the nuclear factor kappa B pathway: a randomized experimental study. J Surg Res. 2015 Sep;198(1):252-9. doi: 10.1016/j.jss.2015.05.010. Epub 2015 May 14. PubMed PMID: 26038248. 14: Cho IJ, Chung HY, Kim SW, Lee JW, Lee TW, Kim HS, Kim SG, Choi HS, Choi SH, Shin CS, Oh KW, Min YK, Koh JM, Rhee Y, Byun DW, Chung YS, Park JH, Chung DJ, Shong M, Hong EG, Lee CB, Baek KH, Kang MI. Efficacy of a Once-Monthly Pill Containing Ibandronate and Cholecalciferol on the Levels of 25-Hydroxyvitamin D and Bone Markers in Postmenopausal Women with Osteoporosis. Endocrinol Metab (Seoul). 2015 Sep;30(3):272-9. doi: 10.3803/EnM.2015.30.3.272. Epub 2014 Dec 9. PubMed PMID: 25491782; PubMed Central PMCID: PMC4595351. 15: Luger M, Kruschitz R, Marculescu R, Haslacher H, Hoppichler F, Kallay E, Kienbacher C, Klammer C, Kral M, Langer F, Luger E, Prager G, Trauner M, Traussnigg S, Würger T, Schindler K, Ludvik B. The link between obesity and vitamin D in bariatric patients with omega-loop gastric bypass surgery - a vitamin D supplementation trial to compare the efficacy of postoperative cholecalciferol loading (LOAD): study protocol for a randomized controlled trial. Trials. 2015 Aug 5;16:328. doi: 10.1186/s13063-015-0877-9. PubMed PMID: 26242295; PubMed Central PMCID: PMC4524369. 16: Pepe J, Mezzaroma I, Fantauzzi A, Falciano M, Salotti A, Di Traglia M, Diacinti D, Biondi P, Cipriani C, Cilli M, Minisola S. An oral high dose of cholecalciferol restores vitamin D status in deficient postmenopausal HIV-1-infected women independently of protease inhibitors therapy: a pilot study. Endocrine. 2015 Aug 9. [Epub ahead of print] PubMed PMID: 26254790. 17: Jean G, Souberbielle JC, Lechevallier S, Chazot C. Kinetics of serum 25-hydroxyvitamin D in haemodialysis patients treated with monthly oral cholecalciferol. Clin Kidney J. 2015 Aug;8(4):388-92. doi: 10.1093/ckj/sfv052. Epub 2015 Jun 30. PubMed PMID: 26251704; PubMed Central PMCID: PMC4515907. 18: Zitt E, Sprenger-Mähr H, Mündle M, Lhotta K. Efficacy and safety of body weight-adapted oral cholecalciferol substitution in dialysis patients with vitamin D deficiency. BMC Nephrol. 2015 Aug 4;16:128. doi: 10.1186/s12882-015-0116-3. PubMed PMID: 26238347; PubMed Central PMCID: PMC4523023. 19: Rousseau AF, Damas P, Ledoux D, Lukas P, Carlisi A, Le Goff C, Gadisseur R, Cavalier E. Vitamin D status after a high dose of cholecalciferol in healthy and burn subjects. Burns. 2015 Aug;41(5):1028-34. doi: 10.1016/j.burns.2014.11.011. Epub 2014 Dec 17. PubMed PMID: 25529268. 20: Satué M, Ramis JM, Monjo M. Cholecalciferol synthesized after UV-activation of 7-dehydrocholesterol onto titanium implants inhibits osteoclastogenesis in vitro. J Biomed Mater Res A. 2015 Jul;103(7):2280-8. doi: 10.1002/jbm.a.35364. Epub 2014 Nov 12. PubMed PMID: 25369149.