GSK0660 is a selective PPARδ antagonist. GSK0660 differentially regulated 273 transcripts in TNFα-treated cells compared to TNFα alone. A pathway analysis revealed the enrichment of cytokine-cytokine receptor signaling. In particular, GSK0660 blocks the TNFα-induced upregulation of CCL8, a chemokine involved in leukocyte recruitment. GSK0660 blocks the effect of TNFα on the expressions of cytokines involved in leukocyte recruitment, including CCL8, CCL17, and CXCL10 and it may therefore block TNFα-induced retinal leukostasis.
MedKoo Cat#: 407221
Name: GSK0660
CAS#: 1014691-61-2
Chemical Formula: C19H18N2O5S2
Exact Mass: 418.0657
Molecular Weight: 418.48
Elemental Analysis: C, 54.53; H, 4.34; N, 6.69; O, 19.12; S, 15.32
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.3 | 139.27 | |
| DMF | 20.0 | 47.79 | |
| DMF:PBS (pH 7.2) (1:3) | 0.3 | 0.60 | |
| Ethanol | 3.1 | 7.38 |
The following data is based on the product molecular weight 418.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
