TMC-205 | CAS#403646-00-4 | transcriptional up-regulator

MedKoo Cat#: 407216 | Name: TMC-205

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MC-205 is a new transcriptional up-regulator and a natural fungal metabolite with antiproliferative activity against cancer cell lines. Expression of the luciferase activity was activated ca. 2-, 4-, and 6-fold by 1, 10, and 100 microM TMC-205, respectively. TMC-205 activated the transcriptional activity in a manner dependent on the presence of the enhancer element of SV40 in its promoter region.

Chemical Structure

TMC-205

CAS#403646-00-4

Theoretical Analysis

MedKoo Cat#: 407216

Name: TMC-205

CAS#: 403646-00-4

Chemical Formula: C14H13NO2

Exact Mass: 227.0946

Molecular Weight: 227.26

Elemental Analysis: C, 73.99; H, 5.77; N, 6.16; O, 14.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

TMC-205; TMC 205; TMC205.

IUPAC/Chemical Name

(E)-6-(3-methylbuta-1,3-dien-1-yl)-1H-indole-3-carboxylic acid

InChi Key

DGRQZYNJXNNHBY-ONEGZZNKSA-N

InChi Code

InChI=1S/C14H13NO2/c1-9(2)3-4-10-5-6-11-12(14(16)17)8-15-13(11)7-10/h3-8,15H,1H2,2H3,(H,16,17)/b4-3+

SMILES Code

O=C(C1=CNC2=C1C=CC(/C=C/C(C)=C)=C2)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 227.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gao Y, Osman S, Koide K. Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter. ACS Med Chem Lett. 2014 Jun 23;5(8):863-7. doi: 10.1021/ml500025p. eCollection 2014 Aug 14. PubMed PMID: 25147604; PubMed Central PMCID: PMC4137371. 2: Sakurai M, Kohno J, Nishio M, Yamamoto K, Okuda T, Kawano K, Nakanishi N. TMC-205 a new transcriptional up-regulator of SV40 promoter produced by an unidentified fungus. Fermentation, isolation, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo). 2001 Aug;54(8):628-34. PubMed PMID: 11592499.