MedKoo Cat#: 317312 | Name: Bentiromide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. It is given by mouth as a noninvasive test. The amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.

Chemical Structure

Bentiromide
Bentiromide
CAS#37106-97-1

Theoretical Analysis

MedKoo Cat#: 317312

Name: Bentiromide

CAS#: 37106-97-1

Chemical Formula: C23H20N2O5

Exact Mass: 404.1372

Molecular Weight: 404.42

Elemental Analysis: C, 68.31; H, 4.98; N, 6.93; O, 19.78

Price and Availability

Size Price Availability Quantity
250mg USD 350.00 2 weeks
1g USD 750.00 2 weeks
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Related CAS #
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Synonym
Bentiromide; Bentiromido; Bentiromidum; CHEBI:31263; PFT; BTPABA; PFT; Bz-tyr-4-abz-oh
IUPAC/Chemical Name
(S)-4-(2-benzamido-3-(4-hydroxyphenyl)propanamido)benzoic acid
InChi Key
SPPTWHFVYKCNNK-FQEVSTJZSA-N
InChi Code
InChI=1S/C23H20N2O5/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30)/t20-/m0/s1
SMILES Code
O=C(O)C1=CC=C(NC([C@@H](NC(C2=CC=CC=C2)=O)CC3=CC=C(O)C=C3)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMSO 250.0 618.17
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 404.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Egesel T, Unsal I, Dikmen G, Bayraktar Y. The assessment of pancreatic exocrine function by bentiromide test in patients with chronic portal vein thrombosis. Pancreas. 2002 Nov;25(4):355-9. PubMed PMID: 12409829. 2: Chung JB, Park SW, Song SY, Moon YM, Kang JK, Park IS. Comparative study of bentiromide test and endoscopic retrograde pancreatography in patients with chronic pancreatitis. Yonsei Med J. 1998 Feb;39(1):45-9. PubMed PMID: 9529984. 3: Oyama H, Watanabe S. [PFD test (bentiromide test, BT-PABA test)]. Nihon Rinsho. 1997 Apr;55 Suppl 2:202-5. Review. Japanese. PubMed PMID: 9172506. 4: Durie PR, Yung-Jato LY, Soldin SJ, Verjee Z, Ellis L. Bentiromide test using liquid-chromatographic measurement of p-aminobenzoic acid and its metabolites for diagnosing pancreatic insufficiency in childhood. J Pediatr. 1992 Sep;121(3):413-6. PubMed PMID: 1517919. 5: Laufer D, Cleghorn G, Forstner G, Ellis L, Koren G, Durie P. The bentiromide test using plasma p-aminobenzoic acid for diagnosing pancreatic insufficiency in young children. The effect of two different doses and a liquid meal. Gastroenterology. 1991 Jul;101(1):207-13. PubMed PMID: 2044909. 6: Bujanover Y, Harel A, Geter R, Blau H, Yahav J, Spirer Z. The development of the chymotryptic activity during postnatal life using the bentiromide test. Int J Pancreatol. 1988 Jan-Feb;3(1):53-8. PubMed PMID: 3258344. 7: Meyer BM, Campbell DR, Curington CW, Toskes PP. Bentiromide test is not affected in patients with small bowel disease or liver disease. Pancreas. 1987;2(1):44-7. PubMed PMID: 3494995. 8: Berg JD, Chesner IM, Allen-Narker RA, Buckley BM, Lawson N. Exocrine pancreatic function as determined in a same-day test with use of bentiromide and p-aminosalicylic acid. Clin Chem. 1986 Jun;32(6):1010-2. PubMed PMID: 3486726. 9: Hawkins EC, Meric SM, Washabau RJ, Feldman EC, Turrel JM. Digestion of bentiromide and absorption of xylose in healthy cats and absorption of xylose in cats with infiltrative intestinal disease. Am J Vet Res. 1986 Mar;47(3):567-9. PubMed PMID: 3485942. 10: Ertan A, Degertekin H, Akdamar K, Godiwala T, Mather F. A new criterion in the assessment of bentiromide as a test of exocrine pancreatic function in alcoholics. Pancreas. 1986;1(2):176-9. PubMed PMID: 3494993. 11: Patel VP, Jain NK, Agarwal N, GeeVarghese PJ, Pitchumoni CS. Comparison of bentiromide test and rice flour breath hydrogen test in the detection of exocrine pancreatic insufficiency. Pancreas. 1986;1(2):172-5. PubMed PMID: 3494992. 12: Koren G, Weizman Z, Forstner G, MacLeod SM, Durie PR. Altered PABA pharmacokinetics in cystic fibrosis. Implications for bentiromide test. Dig Dis Sci. 1985 Oct;30(10):928-32. PubMed PMID: 3875462. 13: Heyman MB. The bentiromide test: how good is it? Gastroenterology. 1985 Sep;89(3):685-7. PubMed PMID: 3874805. 14: Weizman Z, Forstner GG, Gaskin KJ, Kopelman H, Wong S, Durie PR. Bentiromide test for assessing pancreatic dysfunction using analysis of para-aminobenzoic acid in plasma and urine. Studies in cystic fibrosis and Shwachman's syndrome. Gastroenterology. 1985 Sep;89(3):596-604. PubMed PMID: 3874804. 15: Gharbo SA, Boyer JA, Williamson MJ. Colorimetric plasma assay for the bentiromide test (BT-PABA) for exocrine pancreatic insufficiency. Anal Biochem. 1985 Jul;148(1):228-32. PubMed PMID: 3876041. 16: Zimmer JF, Todd SE. Further evaluation of bentiromide in the diagnosis of canine exocrine pancreatic insufficiency. Cornell Vet. 1985 Jul;75(3):426-40. PubMed PMID: 3874751. 17: Karnes HT, Riley CM, Curry SH, Schulman SG. Analysis of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (bentiromide) metabolites in urine by ion-pair high-performance liquid chromatography. J Chromatogr. 1985 Mar 22;338(2):377-88. PubMed PMID: 3873465. 18: Hubbard VS, Wolf RO, Lester LA, Egge AC. Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis. Comparison with other tests of exocrine pancreatic disease. Dig Dis Sci. 1984 Oct;29(10):881-9. PubMed PMID: 6206989. 19: Karnes HT, Bateh RP, Winefordner JD, Schulman SG. Determination of p-aminobenzoic acid in urine by room-temperature phosphorimetry, with application to the bentiromide test for pancreatic function. Clin Chem. 1984 Sep;30(9):1565-7. PubMed PMID: 6331913. 20: Bentiromide--a test of pancreatic insufficiency. Med Lett Drugs Ther. 1984 May 11;26(661):50. PubMed PMID: 6609300.