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MedKoo Cat#: 407196 | Name: AMI-1 disodium salt
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMI-1 is a potent and selective arginine methyltransferase inhibitor, is also a potent scavenger of NADPH-oxidase-derived superoxide. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements.

Chemical Structure

AMI-1 disodium salt
AMI-1 disodium salt
CAS#20324-87-2

Theoretical Analysis

MedKoo Cat#: 407196

Name: AMI-1 disodium salt

CAS#: 20324-87-2

Chemical Formula: C21H14N2Na2O9S2

Exact Mass: 0.0000

Molecular Weight: 548.45

Elemental Analysis: C, 45.99; H, 2.57; N, 5.11; Na, 8.38; O, 26.25; S, 11.69

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
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Synonym
AMI-1; AMI 1; AMI1; AMI-1 disodium salt.
IUPAC/Chemical Name
Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
InChi Key
MOUNHKKCIGVIDI-UHFFFAOYSA-L
InChi Code
InChI=1S/C21H16N2O9S2.2Na/c24-19-9-15(33(27,28)29)7-11-5-13(1-3-17(11)19)22-21(26)23-14-2-4-18-12(6-14)8-16(10-20(18)25)34(30,31)32;;/h1-10,24-25H,(H2,22,23,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2
SMILES Code
O=C(NC1=CC2=CC(S(=O)([O-])=O)=CC(O)=C2C=C1)NC3=CC4=CC(S(=O)([O-])=O)=CC(O)=C4C=C3.[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 548.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PMID: 3087961; PMCID: PMC212883. 8: Dong SH, Wang X, Tian SC, Ma NQ, Zhang XY, Liu Y, Zhang BL, Wu YJ. Arginine methyltransferase inhibitor 1 exhibits antitumor effects against cervical cancer in vitro and in vivo. Pharmazie. 2018 May 1;73(5):269-273. doi: 10.1691/ph.2018.8365. PMID: 29724292. 9: Zhu Y, Yu C, Zhuang S. Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling. Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F375-F387. doi: 10.1152/ajprenal.00487.2019. Epub 2019 Dec 9. PMID: 31813251; PMCID: PMC7052653. 10: Chen F, Fulton DJ. An inhibitor of protein arginine methyltransferases, 7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), is a potent scavenger of NADPH-oxidase-derived superoxide. Mol Pharmacol. 2010 Feb;77(2):280-7. doi: 10.1124/mol.109.061077. Epub 2009 Nov 10. PMID: 19903831; PMCID: PMC3202478. 11: Milohanic E, Jonquières R, Glaser P, Dehoux P, Jacquet C, Berche P, Cossart P, Gaillard JL. Sequence and binding activity of the autolysin-adhesin Ami from epidemic Listeria monocytogenes 4b. Infect Immun. 2004 Aug;72(8):4401-9. doi: 10.1128/IAI.72.8.4401-4409.2004. PMID: 15271896; PMCID: PMC470693. 12: Waxman DA, Kanzaria HK, Schriger DL. Unrecognized Cardiovascular Emergencies Among Medicare Patients. JAMA Intern Med. 2018 Apr 1;178(4):477-484. doi: 10.1001/jamainternmed.2017.8628. PMID: 29482196; PMCID: PMC5876812. 13: Liu W, Sivaprakasam M, Singh PR, Bashirullah R, Wang G. Electronic visual prosthesis. Artif Organs. 2003 Nov;27(11):986-95. doi: 10.1046/j.1525-1594.2003.07306.x. PMID: 14616517. 14: Ródenas-Alesina E, Cabeza-Martínez P, Zamora-Putin V, Pariggiano I, Escalona R, Belahnech Y, Delgado de la Cruz M, Calabrò P, Ferreira-González I, Bañeras J. Long-Term Variation in Kidney Function and Its Impact After Acute Myocardial Infarction. Am J Cardiol. 2022 Jan 15;163:20-24. doi: 10.1016/j.amjcard.2021.09.050. Epub 2021 Nov 9. PMID: 34763827. 15: Lee CW, Hwang I, Park CS, Lee H, Park DW, Kang SJ, Lee SH, Kim YH, Park SW, Park SJ. Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. J Clin Pathol. 2011 May;64(5):399-404. doi: 10.1136/jcp.2010.088484. Epub 2011 Feb 23. PMID: 21345877. 16: Bajbouj K, Ramakrishnan RK, Saber-Ayad M, Omar HA, Saheb Sharif-Askari N, Shafarin J, Elmoselhi AB, Ihmaid A, AlHaj Ali S, Alalool A, Abdullah R, Hamid Q. PRMT5 Selective Inhibitor Enhances Therapeutic Efficacy of Cisplatin in Lung Cancer Cells. Int J Mol Sci. 2021 Jun 7;22(11):6131. doi: 10.3390/ijms22116131. PMID: 34200178; PMCID: PMC8201369. 17: Yoshioka G, Tanaka A, Watanabe N, Nishihira K, Natsuaki M, Kawaguchi A, Shibata Y, Node K. Prognostic impact of incident left ventricular systolic dysfunction after myocardial infarction. Front Cardiovasc Med. 2022 Sep 29;9:1009691. doi: 10.3389/fcvm.2022.1009691. PMID: 36247437; PMCID: PMC9557083. 18: Sun Q, Yang X, Zhong B, Jiao F, Li C, Li D, Lan X, Sun J, Lu S. Upregulated protein arginine methyltransferase 1 by IL-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats. J Immunol. 2012 Apr 1;188(7):3506-12. doi: 10.4049/jimmunol.1102635. Epub 2012 Mar 2. PMID: 22387551. 19: Delgado-Montero A, Martinez-Legazpi P, Desco MM, Rodríguez-Pérez D, Díaz- Otero F, Rossini L, Pérez Del Villar C, Rodríguez-González E, Chazo C, Benito Y, Flores O, Antoranz JC, Fernández-Avilés F, Del Álamo JC, Bermejo J. Blood Stasis Imaging Predicts Cerebral Microembolism during Acute Myocardial Infarction. J Am Soc Echocardiogr. 2020 Mar;33(3):389-398. doi: 10.1016/j.echo.2019.09.020. Epub 2019 Dec 5. PMID: 31813676. 20: Li T, Kong AN, Ma Z, Liu H, Liu P, Xiao Y, Jiang X, Wang L. Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant. Oncotarget. 2016 Apr 12;7(15):20236-48. doi: 10.18632/oncotarget.7752. PMID: 26934120; PMCID: PMC4991450.