PI3065 is a p110δ isoform of phosphoinositide-3-OH kinase (PI(3)K) inhibitor. Inhibitors against the p110δ isoform of phosphoinositide-3-OH kinase (PI(3)K) have shown remarkable therapeutic efficacy in some human leukaemias. As p110δ is primarily expressed in leukocytes, drugs against p110δ have not been considered for the treatment of solid tumours. p110δ inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour regression. p110δ inhibitors can break tumour-induced immune tolerance and should be considered for wider use in oncology
MedKoo Cat#: 407192
Name: PI-3065
CAS#: 955977-50-1
Chemical Formula: C27H31FN6OS
Exact Mass: 506.2264
Molecular Weight: 506.64
Elemental Analysis: C, 64.01; H, 6.17; F, 3.75; N, 16.59; O, 3.16; S, 6.33
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMSO | 10.0 | 19.70 |
The following data is based on the product molecular weight 506.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
