Acetohexamide | CAS#968-81-0 | MedKoo Biosciences

MedKoo Cat#: 317155 | Name: Acetohexamide

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acetohexamide is a sulfonylurea derivative. Acetohexamide is a hyopglycemic agent with moderate uricosuric activity. Acetohexamide is a first generation medication used in the treatment of diabetes metilus type 2.

Chemical Structure

Acetohexamide

CAS#968-81-0

Theoretical Analysis

MedKoo Cat#: 317155

Name: Acetohexamide

CAS#: 968-81-0

Chemical Formula: C15H20N2O4S

Exact Mass: 324.1144

Molecular Weight: 324.40

Elemental Analysis: C, 55.54; H, 6.21; N, 8.64; O, 19.73; S, 9.88

Price and Availability

Size	Price	Availability
50mg	USD 250.00	2 Weeks
100mg	USD 400.00	2 Weeks
500mg	USD 850.00	2 Weeks

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Related CAS #

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Synonym

Acetohexamide; Acetohexamid; Dymelor; Hypoglicil; Gamadiabet; Dimelin; Dimelor; Acetohexamida; Acetohexamidum; NSC759128; NSC 759128 NSC-759128

IUPAC/Chemical Name

1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea

InChi Key

VGZSUPCWNCWDAN-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19)

SMILES Code

CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2CCCCC2

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 324.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Aldawsari H, Altaf A, Banjar ZM, Iohara D, Nakabayashi M, Anraku M, Uekama K, Hirayama F. Crystallization of a new polymorph of acetohexamide from 2-hydroxybutyl-β-cyclodextrin solution: form VI with a high aqueous solubility. Int J Pharm. 2013 Sep 10;453(2):315-21. doi: 10.1016/j.ijpharm.2013.06.026. Epub 2013 Jun 21. PubMed PMID: 23796835. 2: Kretschy N, Teichmann M, Kopf S, Atanasov AG, Saiko P, Vonach C, Viola K, Giessrigl B, Huttary N, Raab I, Krieger S, Jäger W, Szekeres T, Nijman SM, Mikulits W, Dirsch VM, Dolznig H, Grusch M, Krupitza G. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108(3):570-8. doi: 10.1038/bjc.2012.580. Epub 2013 Jan 8. PubMed PMID: 23299527; PubMed Central PMCID: PMC3593542. 3: Joseph KS, Anguizola J, Jackson AJ, Hage DS. Chromatographic analysis of acetohexamide binding to glycated human serum albumin. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15;878(28):2775-81. doi: 10.1016/j.jchromb.2010.08.021. Epub 2010 Aug 21. PubMed PMID: 20829128; PubMed Central PMCID: PMC2952882. 4: Tokunaga H, Uchino T. [Studies for analyzing the prohibited ingredients such as acetohexamide in cosmetics]. Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2005;(123):19-22. Japanese. PubMed PMID: 16541746. 5: Imamura Y, Shimada H. Differential pharmacokinetics of acetohexamide in male Wistar-Imamichi and Sprague-Dawley rats: role of microsomal carbonyl reductase. Biol Pharm Bull. 2005 Jan;28(1):185-7. PubMed PMID: 15635190. 6: Imamura Y, Kaneko M, Takada H, Otagiri M, Shimada H, Akita H. Sex-dependent pharmacokinetics of S(-)-hydroxyhexamide, a pharmacologically active metabolite of acetohexamide, in rats. Comp Biochem Physiol C Toxicol Pharmacol. 2002 Dec;133(4):587-92. PubMed PMID: 12458186. 7: Shimada H, Yamaguchi S, Murata H, Otagiri M, Imamura Y. Cadmium exposure decreases androgen-dependent metabolism of acetohexamide in liver microsomes of male rats through its testicular toxicity. Arch Toxicol. 2002 Feb;76(1):8-12. Epub 2001 Dec 20. PubMed PMID: 11875619. 8: Imamura Y, Sanai K, Seri K, Akita H. Hypoglycemic effect of S(-)-hydroxyhexamide, a major metabolite of acetohexamide, and its enantiomer R(+)-hydroxyhexamide. Life Sci. 2001 Sep 7;69(16):1947-55. PubMed PMID: 11693275. 9: Imamura Y, Uchida A, Takada H, Otagiri M, Tsuchiya K. [Strain-, sex- and species-related differences of acetohexamide reductase and 20 beta-hydroxysteroid dehydrogenase activities in liver microsomes of experimental animals]. Yakugaku Zasshi. 2001 Jan;121(1):85-91. Japanese. PubMed PMID: 11201165. 10: Imamura Y, Koga T, Uriu Y, Otagiri M, Satoh K, Hara A. Catalytic properties for naphthoquinones and partial primary structure of rabbit heart acetohexamide reductase. Biol Pharm Bull. 2000 Feb;23(2):155-8. PubMed PMID: 10706377.