RS-504393 | CCR2 antagonist | CAS#300816-15-3

MedKoo Cat#: 522415 | Name: RS-504393

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RS-504393 is an extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 µM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). It inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.

Chemical Structure

RS-504393

CAS#300816-15-3

Theoretical Analysis

MedKoo Cat#: 522415

Name: RS-504393

CAS#: 300816-15-3

Chemical Formula: C25H27N3O3

Exact Mass: 417.2052

Molecular Weight: 417.51

Elemental Analysis: C, 71.92; H, 6.52; N, 10.06; O, 11.50

Price and Availability

Size	Price	Availability
1mg	USD 300.00	2 Weeks
5mg	USD 450.00	2 Weeks
10mg	USD 700.00	2 Weeks
25mg	USD 950.00	2 Weeks

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Related CAS #

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Synonym

RS504393; RS 504393; RS-504393.

IUPAC/Chemical Name

6-Methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

InChi Key

ODNICNWASXKNNQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)

SMILES Code

CC1=CC2=C(C=C1)NC(=O)OC23CCN(CC3)CCC4=C(OC(=N4)C5=CC=CC=C5)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 417.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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