PF-06471553 is a potent and selective Monoacylglycerol acyltransferase 3 (MGAT3) inhibitor. PF-06471553 selectively inhibits MGAT3 with high in vitro potency and cell efficacy. In the presence of a combination of diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2) inhibitors, an oral administration of PF-06471553 exhibited inhibition of the incorporation of deuterium-labeled glycerol into TAG in mouse model. Inhibition of triacylglycerol (TAG) biosynthetic enzymes has been suggested as a promising strategy to treat insulin resistance, diabetes, dyslipidemia, and hepatic steatosis.
MedKoo Cat#: 522408
Name: PF-06471553
CAS#: 1808094-07-6
Chemical Formula: C23H25N5O4S
Exact Mass: 467.1627
Molecular Weight: 467.54
Elemental Analysis: C, 59.09; H, 5.39; N, 14.98; O, 13.69; S, 6.86
The following data is based on the product molecular weight 467.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
