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MedKoo Cat#: 522402 | Name: MDL-105519

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDL-105519 is a high affinity NMDA glutamate receptor antagonist at the glycine site. MDL 105,519 prevented harmaline-stimulated increases in cerebellar cyclic GMP content, providing biochemical evidence of NMDA receptor antagonism in vivo. This antagonism was associated with anticonvulsant activity in genetically based, chemically induced, and electrically mediated seizure models.

Chemical Structure

MDL-105519
MDL-105519
CAS#161230-88-2

Theoretical Analysis

MedKoo Cat#: 522402

Name: MDL-105519

CAS#: 161230-88-2

Chemical Formula: C18H11Cl2NO4

Exact Mass: 375.0065

Molecular Weight: 376.18

Elemental Analysis: C, 57.47; H, 2.95; Cl, 18.85; N, 3.72; O, 17.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
MDL-105519; MDL 105519; MDL105519; MDL105,519; MDL-105,519; MDL 105,519
IUPAC/Chemical Name
(E)-3-(2-carboxy-2-phenylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acid
InChi Key
LPWVUDLZUVBQGP-DHZHZOJOSA-N
InChi Code
InChI=1S/C18H11Cl2NO4/c19-10-6-13(20)15-12(16(18(24)25)21-14(15)7-10)8-11(17(22)23)9-4-2-1-3-5-9/h1-8,21H,(H,22,23)(H,24,25)/b11-8+
SMILES Code
ClC1=C2C(NC(C(O)=O)=C2/C=C(C3=CC=CC=C3)/C(O)=O)=CC(Cl)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kakuda T, Nozawa A, Sugimoto A, Niino H. Inhibition by theanine of binding of [3H]AMPA, [3H]kainate, and [3H]MDL 105,519 to glutamate receptors. Biosci Biotechnol Biochem. 2002 Dec;66(12):2683-6. PubMed PMID: 12596867. 2: Sharma TA, Reynolds IJ. Complex polyamine effects on [3H]MDL 105,519 binding to the NMDA receptor glycine site. Neurochem Int. 1998 Aug;33(2):155-9. PubMed PMID: 9761459. 3: Chazot PL, Reiss C, Chopra B, Stephenson FA. [3H]MDL 105,519 binds with equal high affinity to both assembled and unassembled NR1 subunits of the NMDA receptor. Eur J Pharmacol. 1998 Jul 17;353(1):137-40. PubMed PMID: 9721050. 4: Höfner G, Wanner KT. Characterisation of the binding of [3H]MDL 105,519, a radiolabelled antagonist for the N-methyl-D-aspartate-associated glycine site, to pig cortical brain membranes. Neurosci Lett. 1997 Apr 25;226(2):79-82. PubMed PMID: 9159494. 5: Baron BM, Harrison BL, Kehne JH, Schmidt CJ, van Giersbergen PL, White HS, Siegel BW, Senyah Y, McCloskey TC, Fadayel GM, Taylor VL, Murawsky MK, Nyce P, Salituro FG. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. Eur J Pharmacol. 1997 Apr 4;323(2-3):181-92. PubMed PMID: 9128837. 6: Siegel BW, Sreekrishna K, Baron BM. Binding of the radiolabeled glycine site antagonist [3H]MDL 105,519 to homomeric NMDA-NR1a receptors. Eur J Pharmacol. 1996 Oct 3;312(3):357-65. PubMed PMID: 8894619. 7: Baron BM, Siegel BW, Harrison BL, Gross RS, Hawes C, Towers P. [3H]MDL 105,519, a high-affinity radioligand for the N-methyl-D-aspartate receptor-associated glycine recognition site. J Pharmacol Exp Ther. 1996 Oct;279(1):62-8. PubMed PMID: 8858976.