MedKoo Cat#: 522356 | Name: BRL54443
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BRL54443 is a potent 5-ht1E/1F receptor agonist.

Chemical Structure

BRL54443
BRL54443
CAS#57477-39-1

Theoretical Analysis

MedKoo Cat#: 522356

Name: BRL54443

CAS#: 57477-39-1

Chemical Formula: C14H18N2O

Exact Mass: 230.1419

Molecular Weight: 230.31

Elemental Analysis: C, 73.01; H, 7.88; N, 12.16; O, 6.95

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 4,650.00 2 Weeks
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Related CAS #
No Data
Synonym
BRL54443; BRL-54443; BRL 54443.
IUPAC/Chemical Name
3-(1-methylpiperidin-4-yl)-1H-indol-5-ol
InChi Key
WKNFADCGOAHBPG-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H18N2O/c1-16-6-4-10(5-7-16)13-9-15-14-3-2-11(17)8-12(13)14/h2-3,8-10,15,17H,4-7H2,1H3
SMILES Code
CN1CCC(C2=CNC3=C2C=C(O)C=C3)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 230.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nelson PM, Harrod JS, Lamping KG. 5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes. Exp Diabetes Res. 2012;2012:398406. doi: 10.1155/2012/398406. Epub 2012 Dec 30. PubMed PMID: 23346101; PubMed Central PMCID: PMC3546478. 2: Klein MT, Teitler M. Distribution of 5-ht(1E) receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study. Br J Pharmacol. 2012 Jun;166(4):1290-302. doi: 10.1111/j.1476-5381.2012.01868.x. PubMed PMID: 22260342; PubMed Central PMCID: PMC3417447. 3: Klein MT, Dukat M, Glennon RA, Teitler M. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7. doi: 10.1124/jpet.111.179606. Epub 2011 Mar 21. PubMed PMID: 21422162; PubMed Central PMCID: PMC3101003. 4: Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8. doi: 10.1016/j.neuroscience.2009.10.020. Epub . PubMed PMID: 19837141. 5: Watts SW, Yang P, Banes AK, Baez M. Activation of Erk mitogen-activated protein kinase proteins by vascular serotonin receptors. J Cardiovasc Pharmacol. 2001 Oct;38(4):539-51. PubMed PMID: 11588524.