Diosgenin, a steroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. The sugar-free (aglycone) diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products. Diosgenin is the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills. The unmodified steroid has estrogenic activity and can reduce the level of serum cholesterol. (Source: http://en.wikipedia.org/wiki/Diosgenin).
MedKoo Cat#: 600129
Name: Diosgenin
CAS#: 512-04-9
Chemical Formula: C27H42O3
Exact Mass: 414.3134
Molecular Weight: 414.63
Elemental Analysis: C, 78.21; H, 10.21; O, 11.58
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 72.35 | |
| DMSO | 15.5 | 37.38 | |
| Ethanol | 13.2 | 31.89 | |
| Ethanol:PBS (pH 7.2) (1:2) | 0.3 | 0.72 |
The following data is based on the product molecular weight 414.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
