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MedKoo Cat#: 600124 | Name: Corosolic acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Corosolic acid is a pentacyclic triterpene acid found in Lagerstroemia speciosa. It is similar in structure to ursolic acid, differing only in the fact that it has a 2-alpha-hydroxy attachment. Corosolic acid has numerous biological properties, including antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. However, there is a lack of clinical evidence to support these uses.

Chemical Structure

Corosolic acid
CAS#4547-24-4

Theoretical Analysis

MedKoo Cat#: 600124

Name: Corosolic acid

CAS#: 4547-24-4

Chemical Formula: C30H48O4

Exact Mass: 472.3553

Molecular Weight: 472.70

Elemental Analysis: C, 76.23; H, 10.24; O, 13.54

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 615.00 2 Weeks
100mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
Corosolic acid; Corsolic acid; Glucosol; Colosic acid; Colosolic acid; 2α-Hydroxyursolic Acid;
IUPAC/Chemical Name
(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid
InChi Key
HFGSQOYIOKBQOW-ZSDYHTTISA-N
InChi Code
InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
SMILES Code
CC1(C)[C@@H](O)[C@H](O)C[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO.
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity.
In vitro activity:
Results demonstrated that corosolic acid could prevent NRG1-induced HER2/HER3 heterodimerization and suppress the phosphorylation of both HER2 and HER3. Furthermore, HER2 and HER3 could regulate the downstream signalling pathways of RalA/RalBP1/CDK1 and PI3K/Akt/PKA, respectively, resulting in the changes in phosphorylation of Drp1 and mitochondrial dynamics. Reference: Br J Pharmacol. 2021 Mar;178(6):1475-1491. https://pubmed.ncbi.nlm.nih.gov/33443775/
In vivo activity:
After Dox injury, compared with the control group, CRA (corosolic acid) increased the survival rate of mice, improved the cardiac function, decreased the oxidative stress, and reduced the apoptosis. Reference: Cell Biol Toxicol. 2021 Jul 22. https://pubmed.ncbi.nlm.nih.gov/34296331/
Solvent mg/mL mM comments
Solubility
DMSO 55.0 116.35
DMF 14.0 29.62
Ethanol 8.5 17.98
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 472.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Zhang BY, Zhang L, Chen YM, Qiao X, Zhao SL, Li P, Liu JF, Wen X, Yang J. Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor. Br J Pharmacol. 2021 Mar;178(6):1475-1491. doi: 10.1111/bph.15372. Epub 2021 Feb 17. PMID: 33443775. 2. Jia M, Xiong Y, Li M, Mao Q. Corosolic Acid Inhibits Cancer Progress Through Inactivating YAP in Hepatocellular Carcinoma. Oncol Res. 2020 Sep 1;28(4):371-383. doi: 10.3727/096504020X15853075736554. Epub 2020 Mar 27. PMID: 32220262; PMCID: PMC7851517. 3. Che Y, Wang Z, Yuan Y, Zhou H, Wu H, Wang S, Tang Q. By restoring autophagic flux and improving mitochondrial function, corosolic acid protects against Dox-induced cardiotoxicity. Cell Biol Toxicol. 2021 Jul 22. doi: 10.1007/s10565-021-09619-8. Epub ahead of print. PMID: 34296331. 4. Liu G, Cui Z, Gao X, Liu H, Wang L, Gong J, Wang A, Zhang J, Ma Q, Huang Y, Piao G, Yuan H. Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-β1/Smad2, NF-κB, and AMPK signaling pathways. Phytother Res. 2021 Jul 2. doi: 10.1002/ptr.7195. Epub ahead of print. PMID: 34213784.
In vitro protocol:
1. Zhang BY, Zhang L, Chen YM, Qiao X, Zhao SL, Li P, Liu JF, Wen X, Yang J. Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor. Br J Pharmacol. 2021 Mar;178(6):1475-1491. doi: 10.1111/bph.15372. Epub 2021 Feb 17. PMID: 33443775. 2. Jia M, Xiong Y, Li M, Mao Q. Corosolic Acid Inhibits Cancer Progress Through Inactivating YAP in Hepatocellular Carcinoma. Oncol Res. 2020 Sep 1;28(4):371-383. doi: 10.3727/096504020X15853075736554. Epub 2020 Mar 27. PMID: 32220262; PMCID: PMC7851517.
In vivo protocol:
1. Che Y, Wang Z, Yuan Y, Zhou H, Wu H, Wang S, Tang Q. By restoring autophagic flux and improving mitochondrial function, corosolic acid protects against Dox-induced cardiotoxicity. Cell Biol Toxicol. 2021 Jul 22. doi: 10.1007/s10565-021-09619-8. Epub ahead of print. PMID: 34296331. 2. Liu G, Cui Z, Gao X, Liu H, Wang L, Gong J, Wang A, Zhang J, Ma Q, Huang Y, Piao G, Yuan H. Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-β1/Smad2, NF-κB, and AMPK signaling pathways. Phytother Res. 2021 Jul 2. doi: 10.1002/ptr.7195. Epub ahead of print. PMID: 34213784.
1: Zhao J, Zhou H, An Y, Shen K, Yu L. Biological effects of corosolic acid as an anti-inflammatory, anti-metabolic syndrome and anti-neoplasic natural compound. Oncol Lett. 2021 Feb;21(2):84. doi: 10.3892/ol.2020.12345. Epub 2020 Dec 2. PMID: 33363621; PMCID: PMC7723172. 2: Liu G, Cui Z, Gao X, Liu H, Wang L, Gong J, Wang A, Zhang J, Ma Q, Huang Y, Piao G, Yuan H. Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-β1/Smad2, NF-κB, and AMPK signaling pathways. Phytother Res. 2021 Sep;35(9):5214-5226. doi: 10.1002/ptr.7195. Epub 2021 Jul 2. PMID: 34213784. 3: Zhang BY, Zhang L, Chen YM, Qiao X, Zhao SL, Li P, Liu JF, Wen X, Yang J. Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor. Br J Pharmacol. 2021 Mar;178(6):1475-1491. doi: 10.1111/bph.15372. Epub 2021 Feb 17. PMID: 33443775. 4: Sivakumar G, Vail DR, Nair V, Medina-Bolivar F, Lay JO Jr. Plant-based corosolic acid: future anti-diabetic drug? Biotechnol J. 2009 Dec;4(12):1704-11. doi: 10.1002/biot.200900207. PMID: 19946881. 5: Jin M, Wu Y, Lou Y, Liu X, Dai Y, Yang W, Liu C, Huang G. Corosolic acid reduces A549 and PC9 cell proliferation, invasion, and chemoresistance in NSCLC via inducing mitochondrial and liposomal oxidative stress. Biomed Pharmacother. 2021 Dec;144:112313. doi: 10.1016/j.biopha.2021.112313. Epub 2021 Oct 19. PMID: 34678723. 6: Qian XP, Zhang XH, Sun LN, Xing WF, Wang Y, Sun SY, Ma MY, Cheng ZP, Wu ZD, Xing C, Chen BN, Wang YQ. Corosolic acid and its structural analogs: A systematic review of their biological activities and underlying mechanism of action. Phytomedicine. 2021 Oct;91:153696. doi: 10.1016/j.phymed.2021.153696. Epub 2021 Aug 13. PMID: 34456116. 7: Pundalik S, Hanumappa KR, Giresha AS, Urs D, Rajashekarappa S, Muniyappa N, Jamballi G M, Kuaramkote Shivanna D, S Meti R, Anekere Dasappa Setty S, Thippegowda PB, Krishnappa DK. Corosolic Acid Inhibits Secretory Phospholipase A2IIa as an Anti-Inflammatory Function and Exhibits Anti-Tumor Activity in Ehrlich Ascites Carcinoma Bearing Mice. J Inflamm Res. 2022 Dec 31;15:6905-6921. doi: 10.2147/JIR.S383441. PMID: 36619941; PMCID: PMC9811966. 8: Stohs SJ, Miller H, Kaats GR. A review of the efficacy and safety of banaba (Lagerstroemia speciosa L.) and corosolic acid. Phytother Res. 2012 Mar;26(3):317-24. doi: 10.1002/ptr.3664. Epub 2011 Nov 17. PMID: 22095937. 9: Park JB, Lee JS, Lee MS, Cha EY, Kim S, Sul JY. Corosolic acid reduces 5‑FU chemoresistance in human gastric cancer cells by activating AMPK. Mol Med Rep. 2018 Sep;18(3):2880-2888. doi: 10.3892/mmr.2018.9244. Epub 2018 Jul 3. PMID: 30015846; PMCID: PMC6102703. 10: Peng Y, Li N, Tang F, Qian C, Jia T, Liu J, Xu Y. Corosolic acid sensitizes ferroptosis by upregulating HERPUD1 in liver cancer cells. Cell Death Discov. 2022 Aug 29;8(1):376. doi: 10.1038/s41420-022-01169-0. PMID: 36038536; PMCID: PMC9424261. 11: Woo SM, Seo SU, Min KJ, Im SS, Nam JO, Chang JS, Kim S, Park JW, Kwon TK. Corosolic Acid Induces Non-Apoptotic Cell Death through Generation of Lipid Reactive Oxygen Species Production in Human Renal Carcinoma Caki Cells. Int J Mol Sci. 2018 Apr 27;19(5):1309. doi: 10.3390/ijms19051309. PMID: 29702597; PMCID: PMC5983573. 12: Guo X, Cui R, Zhao J, Mo R, Peng L, Yan M. Corosolic acid protects hepatocytes against ethanol-induced damage by modulating mitogen-activated protein kinases and activating autophagy. Eur J Pharmacol. 2016 Nov 15;791:578-588. doi: 10.1016/j.ejphar.2016.09.031. Epub 2016 Sep 20. PMID: 27663281. 13: Wang ZP, Che Y, Zhou H, Meng YY, Wu HM, Jin YG, Wu QQ, Wang SS, Yuan Y. Corosolic acid attenuates cardiac fibrosis following myocardial infarction in mice. Int J Mol Med. 2020 May;45(5):1425-1435. doi: 10.3892/ijmm.2020.4531. Epub 2020 Mar 9. PMID: 32323841; PMCID: PMC7138284. 14: Alkholifi FK, Devi S, Yusufoglu HS, Alam A. The Cardioprotective Effect of Corosolic Acid in the Diabetic Rats: A Possible Mechanism of the PPAR-γ Pathway. Molecules. 2023 Jan 17;28(3):929. doi: 10.3390/molecules28030929. PMID: 36770602; PMCID: PMC9919720. 15: Zhao J, Zhao W, Xu H, Luan W, Wang X, Fang Y, Yu L. Corosolic acid inhibits tumour growth without compromising associating liver partition and portal vein ligation-induced liver regeneration in rats. Ann Med. 2022 Dec;54(1):1188-1201. doi: 10.1080/07853890.2022.2067893. PMID: 35481406; PMCID: PMC9067999. 16: Wang ZP, Shen D, Che Y, Jin YG, Wang SS, Wu QQ, Zhou H, Meng YY, Yuan Y. Corosolic acid ameliorates cardiac hypertrophy via regulating autophagy. Biosci Rep. 2019 Dec 20;39(12):BSR20191860. doi: 10.1042/BSR20191860. PMID: 31746323; PMCID: PMC6893168. 17: Baba K, Hiramatsu R, Suradej B, Tanigaki R, Koeda S, Waku T, Kataoka T. Asiatic Acid, Corosolic Acid, and Maslinic Acid Interfere with Intracellular Trafficking and N-Linked Glycosylation of Intercellular Adhesion Molecule-1. Biol Pharm Bull. 2018;41(12):1757-1768. doi: 10.1248/bpb.b18-00276. Erratum in: Biol Pharm Bull. 2021;44(9):1348. PMID: 30504678. 18: Yoo KH, Park JH, Lee DY, Hwang-Bo J, Baek NI, Chung IS. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytother Res. 2015 May;29(5):714-23. doi: 10.1002/ptr.5306. Epub 2015 Feb 2. PMID: 25644809. 19: Guo Z, Jing Q, Xu Z, Zhang D, Zheng W, Ren F. Corosolic acid-modified lipid nanoparticles as delivery carriers for DNA vaccines against avian influenza. Int J Pharm. 2023 May 10;638:122914. doi: 10.1016/j.ijpharm.2023.122914. Epub 2023 Apr 5. PMID: 37028571. 20: Zhang L, Sui S, Wang S, Sun J. Neuroprotective Effect of Corosolic Acid Against Cerebral Ischemia-Reperfusion Injury in Experimental Rats. J Oleo Sci. 2022 Sep 30;71(10):1501-1510. doi: 10.5650/jos.ess22130. Epub 2022 Sep 9. PMID: 36089398.

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