Synonym
Epithalon; AlaGluAspGly.
IUPAC/Chemical Name
(S)-4-((S)-2-aminopropanamido)-5-(((S)-3-carboxy-1-((carboxymethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoic acid.
InChi Key
HGHOBRRUMWJWCU-FXQIFTODSA-N
InChi Code
InChI=1S/C14H22N4O9/c1-6(15)12(25)17-7(2-3-9(19)20)14(27)18-8(4-10(21)22)13(26)16-5-11(23)24/h6-8H,2-5,15H2,1H3,(H,16,26)(H,17,25)(H,18,27)(H,19,20)(H,21,22)(H,23,24)/t6-,7-,8-/m0/s1
SMILES Code
O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(NCC(O)=O)=O)=O)[C@H](C)N.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
390.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Vinogradova IA. [Effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity of the hypophysis and thyroid gland function in different light regimes]. Adv Gerontol. 2009;22(4):631-8. Russian. PubMed PMID: 20405731.
2: Sibarov DA, Vol'nova AB, Frolov DS, Nozdrachev AD. Effects of intranasal administration of epitalon on neuron activity in the rat neocortex. Neurosci Behav Physiol. 2007 Nov;37(9):889-93. PubMed PMID: 17955380.
3: Sibarov DA, Vol'nova AB, Frolov DS, Nosdrachev AD. [Intranasal epitalon infusion modulates neuronal activity in the rat neocortex]. Ross Fiziol Zh Im I M Sechenova. 2006 Aug;92(8):949-56. Russian. PubMed PMID: 17217245.
4: Vinogradova IA. [Comparative study of the effects of melatonin and epitalon on the protracted memory under the shuttle labyrinth test conditions in rats in the course of aging]. Eksp Klin Farmakol. 2006 Nov-Dec;69(6):13-6. Russian. PubMed PMID: 17209456.
5: Rendakov NL, Tiutiunnik NN, Vinogradova IA. [Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats]. Adv Gerontol. 2006;19:72-8. Russian. PubMed PMID: 17152724.
6: Svechkina EB, Tiutiunnik NN, Vinogradova IA. [Influence of light regimens, melatonin, and epitalon on amylase activity in the pancreas and small intestine in rats of different age]. Adv Gerontol. 2006;19:66-71. Russian. PubMed PMID: 17152723.
7: Kossoy G, Anisimov VN, Ben-Hur H, Kossoy N, Zusman I. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo. 2006 Mar-Apr;20(2):253-7. PubMed PMID: 16634527.
8: Anisimov VN, Popovich IG, Zabezhinskiĭ MA, Rozenfel'd SV, Khavinson VKh, Semenchenko AV, Iashin AI. [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)]. Vopr Onkol. 2005;51(1):93-8. Russian. PubMed PMID: 15909815.
9: Kuznik BI, Pateiuk AV, Khavinson VKh, Malinin VV. [Effect of epitalon on the immunity and hemostasis in hypophysectomized chicken and old hens]. Adv Gerontol. 2004;13:90-3. Russian. PubMed PMID: 15490730.
10: Khavinson VKh, Lezhava TA, Monaselidze JR, Jokhadze TA, Dvalishvili NA, Bablishvili NK, Trofimova SV. Peptide Epitalon activates chromatin at the old age. Neuro Endocrinol Lett. 2003 Oct;24(5):329-33. PubMed PMID: 14647006.
