Synonym
Prednacinolone; Steroderm; Apolar; D 2083; D2083; D-2083; Locapred; Topifug; Sterax; Budesonide acetonide; Prenacid; Tridesonit; Prednisolone acetonide; Desowen;
IUPAC/Chemical Name
(6aR,7S,8aS,8bS,11aR)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one
InChi Key
WBGKWQHBNHJJPZ-QHDHGWJCSA-N
InChi Code
InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15?,16?,17-,19+,20?,22-,23-,24+/m0/s1
SMILES Code
O=C(C=C[C@@]12C)C=C1CCC(C2[C@@H](O)C[C@@]34C)C3C[C@]5([H])[C@@]4(C(CO)=O)OC(C)(C)O5
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO.
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
69.0 |
165.66 |
| Ethanol |
20.0 |
48.02 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
416.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Yentzer BA, Camacho FT, Young T, Fountain JM, Clark AR, Feldman SR. Good adherence and early efficacy using desonide hydrogel for atopic dermatitis: results from a program addressing patient compliance. J Drugs Dermatol. 2010 Apr;9(4):324-9. PubMed PMID: 20514788.
2: Elewski B. An investigator-blind, randomized, 4-week, parallel-group, multicenter pilot study to compare the safety and efficacy of a nonsteroidal cream (Promiseb Topical Cream) and desonide cream 0.05% in the twice-daily treatment of mild to moderate seborrheic dermatitis of the face. Clin Dermatol. 2009 Nov-Dec;27(6 Suppl):S48-53. PubMed PMID: 19878781.
3: Kircik LH. Treatment of scalp and facial seborrheic dermatitis with desonide hydrogel 0.05%. J Clin Aesthet Dermatol. 2009 Feb;2(2):32-6. PubMed PMID: 20967179; PubMed Central PMCID: PMC2958180.
4: Hebert AA; Desonide Foam Phase III Clinical Study Group. Desonide foam 0.05%: safety in children as young as 3 months. J Am Acad Dermatol. 2008 Aug;59(2):334-40. PubMed PMID: 18638631.
5: Kahanek N, Gelbard C, Hebert A. Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs. 2008 Jul;17(7):1097-104. Review. PubMed PMID: 18549345.
6: Parish D, Scheinfeld N. Desonide foam: a review. Drugs Today (Barc). 2008 Jan;44(1):55-62. Review. PubMed PMID: 18301804.
7: Scheinfeld NS, Parish DH. Desonide gel. Skinmed. 2007 Sep-Oct;6(5):241. PubMed PMID: 17786103.
8: Bhankharia DA, Sanjana PH. Efficacy of desonide 0.05% cream and lotion in steroid-responsive dermatoses in Indian patients: a post-marketing surveillance study. Indian J Dermatol Venereol Leprol. 2004 Sep-Oct;70(5):288-91. PubMed PMID: 17642640.
9: Eichenfield LF, Basu S, Calvarese B, Trancik RJ. Effect of desonide hydrogel 0.05% on the hypothalamic-pituitary-adrenal axis in pediatric subjects with moderate to severe atopic dermatitis. Pediatr Dermatol. 2007 May-Jun;24(3):289-95. PubMed PMID: 17542883.
10: Hebert AA, Cook-Bolden FE, Basu S, Calvarese B, Trancik RJ; Desonide Hydrogel Study Group. Safety and efficacy of desonide hydrogel 0.05% in pediatric subjects with atopic dermatitis. J Drugs Dermatol. 2007 Feb;6(2):175-81. PubMed PMID: 17373176.
