WIKI4 | CAS#838818-26-1 | Tankyrase Inhibitor

MedKoo Cat#: 406349 | Name: WIKI4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WIKI4 is a novel inhibitor of tankyrase and Wnt/ÃŸ-catenin signaling. WIKI4 inhibits expression of ÃŸ-catenin target genes and cellular responses to Wnt/ÃŸ-catenin signaling in cancer cell lines as well as in human embryonic stem cells. WIKI4 mediates its effects on Wnt/ÃŸ-catenin signaling by inhibiting the enzymatic activity of TNKS2, a regulator of AXIN ubiquitylation and degradation. While TNKS has previously been shown to be the target of small molecule inhibitors of Wnt/ÃŸ-catenin signaling, WIKI4 is structurally distinct from previously identified TNKS inhibitors.

Chemical Structure

WIKI4

CAS#838818-26-1

Theoretical Analysis

MedKoo Cat#: 406349

Name: WIKI4

CAS#: 838818-26-1

Chemical Formula: C29H23N5O3S

Exact Mass: 521.1522

Molecular Weight: 521.59

Elemental Analysis: C, 66.78; H, 4.44; N, 13.43; O, 9.20; S, 6.15

Price and Availability

Size	Price	Availability
10mg	USD 120.00	Ready to ship
25mg	USD 250.00	Ready to ship
50mg	USD 425.00	Ready to ship
100mg	USD 700.00	Ready to ship
200mg	USD 1,050.00	Ready to ship
500mg	USD 2,050.00	Ready to ship
1g	USD 3,250.00	2 weeks

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Related CAS #

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Synonym

WIKI4; WIKI 4; WIKI-4

IUPAC/Chemical Name

2-(3-((4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

InChi Key

RNUXIZKXJOGYQP-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H23N5O3S/c1-37-22-11-9-21(10-12-22)34-26(20-13-15-30-16-14-20)31-32-29(34)38-18-4-17-33-27(35)23-7-2-5-19-6-3-8-24(25(19)23)28(33)36/h2-3,5-16H,4,17-18H2,1H3

SMILES Code

O=C(NC1=CC=CC=C1C(NC2=CC=C(CCN3CC4=C(C=C(OC)C(OC)=C4)CC3)C=C2)=O)C5=CC=C(OC)C(OC)=C5

Appearance

White to off-white solid

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs

Storage Condition

0 Â– 4 C for short term (weeks to 1 month) or -20 C for long terms (months to years).

Solubility

soluble in DMSO, not soluble in water.

Shelf Life

>2 years if stored properly.

Drug Formulation

This drug may be formulated in DMSO.

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Certificate of Analysis

View CoA: current batch, Lot#B7B09C21

QC Data

View QC data: current batch, Lot#B7B09C21

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 521.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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