Synonym
TG100713; TG 100713; TG-100713
IUPAC/Chemical Name
3-(2,4-diaminopteridin-6-yl)phenol
InChi Key
UOORQSPLBHUQDQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)
SMILES Code
OC1=CC=CC(C2=NC3=C(N)N=C(N)N=C3N=C2)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
254.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Doukas, J., Wrasidlo, W., Noronha, G., et al. Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc. Natl. Acad. Sci. USA 103(52), 19866-19871 (2006).
2. Vargas, B., Giacobbi, N.S., Sanyal, A., et al. Inhibitors of signaling pathways that block reversal of HIV-1 latency. Antimicrob. Agents Chemother. 63(2), e01744-01718 (2019).
3: Liu Z, Min S, Lu X, Cen S, Chen Z, Wang T, Li J, Zeng W, Qiu S. [Hyperactivation of PI3K/AKT/mTOR signal pathway impairs TNF-α-induced autophagy in mesenchymal stem cells from patients with ankylosing spondylitis]. Nan Fang Yi Ke Da Xue Xue Bao. 2022 Feb 20;42(2):272-277. Chinese. doi: 10.12122/j.issn.1673-4254.2022.02.15. PMID: 35365453; PMCID: PMC8983359.
