5-Ethynyl DU CEP | a clickable nucleoside building block | CAS#615288-66-9

MedKoo Cat#: 129097 | Name: 5-Ethynyl DU CEP

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

5-Ethynyl DU CEP is a clickable nucleoside building block.

Chemical Structure

5-Ethynyl DU CEP

CAS#615288-66-9

Theoretical Analysis

MedKoo Cat#: 129097

Name: 5-Ethynyl DU CEP

CAS#: 615288-66-9

Chemical Formula: C41H47N4O8P

Exact Mass: 754.3132

Molecular Weight: 754.82

Elemental Analysis: C, 65.24; H, 6.28; N, 7.42; O, 16.96; P, 4.10

Price and Availability

Size	Price	Availability
100mg	USD 350.00	2 Weeks
250mg	USD 550.00	2 Weeks
500mg	USD 850.00	2 Weeks

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Related CAS #

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Synonym

5-Ethynyl DU CEP; EdU CEP

IUPAC/Chemical Name

(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-ethynyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

InChi Key

AEBKGWARVNCVEK-VPJZQFIISA-N

InChi Code

InChI=1S/C41H47N4O8P/c1-8-30-26-44(40(47)43-39(30)46)38-25-36(53-54(51-24-12-23-42)45(28(2)3)29(4)5)37(52-38)27-50-41(31-13-10-9-11-14-31,32-15-19-34(48-6)20-16-32)33-17-21-35(49-7)22-18-33/h1,9-11,13-22,26,28-29,36-38H,12,24-25,27H2,2-7H3,(H,43,46,47)/t36-,37+,38+,54?/m0/s1

SMILES Code

COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@H]4O[C@@H](N5C(NC(C(C#C)=C5)=O)=O)C[C@@H]4OP(OCCC#N)N(C(C)C)C(C)C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Biological target:

In vitro activity:

In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 754.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

In vitro protocol:

In vivo protocol:

1. Jakobsen, U., Shelke, S.A., Vogel, S., et al. Site-directed spin-labeling of nucleic acids by click chemistry: Detection of abasic sites in duplex DNA by EPR spectroscopy. J. Am. Chem. Soc. 132(30), 10424-10428 (2010).