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MedKoo Cat#: 129096 | Name: CLK1-IN-3
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CLK1-IN-3 is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A.

Chemical Structure

CLK1-IN-3
CLK1-IN-3
CAS#2922550-28-3

Theoretical Analysis

MedKoo Cat#: 129096

Name: CLK1-IN-3

CAS#: 2922550-28-3

Chemical Formula: C24H23FN6O

Exact Mass: 430.1917

Molecular Weight: 430.49

Elemental Analysis: C, 66.96; H, 5.39; F, 4.41; N, 19.52; O, 3.72

Price and Availability

Size Price Availability Quantity
50mL USD 550.00 2 Weeks
100mg USD 950.00 2 Weeks
200mg USD 1,650.00 2 Weeks
1g USD 4,350.00 2 Weeks
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Related CAS #
No Data
Synonym
CLK1-IN-3; CLK1IN3; CLK1IN-3; CLK1-IN3
IUPAC/Chemical Name
N-(3-(5-fluoropyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-(4-methylpiperazin-1-yl)benzamide
InChi Key
LQKHTRXKHPHEPP-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H23FN6O/c1-30-6-8-31(9-7-30)20-4-2-16(3-5-20)24(32)29-19-11-21-22(15-28-23(21)27-14-19)17-10-18(25)13-26-12-17/h2-5,10-15H,6-9H2,1H3,(H,27,28)(H,29,32)
SMILES Code
CN1CCN(CC1)C2=CC=C(C=C2)C(NC3=CN=C4NC=C(C4=C3)C5=CN=CC(F)=C5)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 430.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Yang T, Yang Y, Chen Y, Tang M, Shi M, Tian Y, Yuan X, Yang Z, Chen L. Rational design and appraisal of selective Cdc2-Like kinase 1 (Clk1) inhibitors as novel autophagy inducers for the treatment of acute liver injury (ALI). Eur J Med Chem. 2023 Mar 15;250:115168. doi: 10.1016/j.ejmech.2023.115168. Epub 2023 Feb 7. PMID: 36780830.