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MedKoo Cat#: 129094 | Name: KBD4466

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KBD4466, a Selective TLR 7/8 Inhibitor, for the Treatment of Autoimmune Diseases. KBD4466 demonstrates excellent cellular activity, favorable pharmacokinetic properties, potent inhibition of cytokine production in mouse pharmacodynamic studies, and outstanding therapeutic efficacy in an SLE animal model.

Chemical Structure

KBD4466
KBD4466
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129094

Name: KBD4466

CAS#: N/A

Chemical Formula: C24H23F3N6O

Exact Mass: 468.1885

Molecular Weight: 468.48

Elemental Analysis: C, 61.53; H, 4.95; F, 12.17; N, 17.94; O, 3.42

Price and Availability

Related CAS #
No Data
Synonym
KBD4466; KBD-4466; KBD 4466
IUPAC/Chemical Name
5-((1S,5R)-1-(5-(1-methylpiperidin-4-yl)-1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-8-carbonitrile
InChi Key
XGERGOZPFHOLSD-NQCNTLBGSA-N
InChi Code
InChI=1S/C24H23F3N6O/c1-32-9-6-15(7-10-32)20-30-31-21(34-20)22-12-23(22,24(25,26)27)14-33(13-22)18-5-4-16(11-28)19-17(18)3-2-8-29-19/h2-5,8,15H,6-7,9-10,12-14H2,1H3/t22-,23?/m0/s1
SMILES Code
CN(CC1)CCC1C2=NN=C(O2)[C@]([C@@]3(C(F)(F)F)C4)(C3)CN4C5=C6C(N=CC=C6)=C(C#N)C=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 468.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Yuan Y, Wei Y, Jia Z, Chu H, Kong D, Lei F, Ye F, Qian X, Zhang J, Zhou X, Zhu X, Li Z, Liang X, Chen W. Discovery of KBD4466, a Selective TLR 7/8 Inhibitor, for the Treatment of Autoimmune Diseases. J Med Chem. 2025 Jul 1. doi: 10.1021/acs.jmedchem.5c00656. Epub ahead of print. PMID: 40591919.