ISM7594 is a Tissue-Agnostic FGFR2/3 Inhibitor. ISM7594 potently inhibited FGFR2/3 and selectively spared FGFR1/4. The “magic methyl” effect played a crucial role in enhancing the activity. ISM7594 maintained strong activity against multiple FGFR2/3 mutants known to drive resistance to current drugs and broads pectrum antiproliferative potency in cancer cells harboring diverse FGFR2/3 alterations, including FGFR2/3 amplification, fusion, and mutation types. The compound demonstrated robust tumor growth suppression, favorable pharmacokinetic profile, and pharmacodynamic effects.
MedKoo Cat#: 129087
Name: ISM7594
CAS#: N/A
Chemical Formula: C29H22F2N6O3
Exact Mass: 540.1721
Molecular Weight: 540.53
Elemental Analysis: C, 64.44; H, 4.10; F, 7.03; N, 15.55; O, 8.88
The following data is based on the product molecular weight 540.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Wang Y, Liu J, Zhang Y, Zhao J, Wang C, Cui H, Meng F, Aliper A, Liang T, Yan F, Ren F, Lan J, Lu Q, Zhou F, Cai X, Ding X, Zhavoronkov A. Rational Design and Identification of ISM7594 as a Tissue-Agnostic FGFR2/3 Inhibitor. J Med Chem. 2025 Jun 25. doi: 10.1021/acs.jmedchem.5c00928. Epub ahead of print. PMID: 40561334.
