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MedKoo Cat#: 129083 | Name: LG1188

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LG1188 is a FGFR1 degrader.

Chemical Structure

LG1188
LG1188
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129083

Name: LG1188

CAS#: N/A

Chemical Formula: C61H76N10O9S

Exact Mass: 1124.5517

Molecular Weight: 1125.40

Elemental Analysis: C, 65.10; H, 6.81; N, 12.45; O, 12.79; S, 2.85

Price and Availability

Related CAS #
No Data
Synonym
LG1188; FGFR1 degrader LG1188; PROTAC LG1188
IUPAC/Chemical Name
(2S,4R)-1-((S)-2-(2-(4-(2-(2-((2R,6S)-4-(4-((5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-2,6-dimethylpiperazin-1-yl)acetamido)ethyl)phenoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChi Key
YTTVAAVPYIYNRH-HHNAXFNBSA-N
InChi Code
InChI=1S/C61H76N10O9S/c1-37-31-69(47-20-17-45(18-21-47)58(75)65-53-28-46(67-68-53)19-10-42-26-50(78-8)30-51(27-42)79-9)32-38(2)70(37)34-54(73)62-25-24-41-11-22-49(23-12-41)80-35-55(74)66-57(61(5,6)7)60(77)71-33-48(72)29-52(71)59(76)64-39(3)43-13-15-44(16-14-43)56-40(4)63-36-81-56/h11-18,20-23,26-28,30,36-39,48,52,57,72H,10,19,24-25,29,31-35H2,1-9H3,(H,62,73)(H,64,76)(H,66,74)(H2,65,67,68,75)/t37-,38+,39-,48+,52-,57+/m0/s1
SMILES Code
C[C@@H]1CN(C2=CC=C(C(NC3=NNC(CCC4=CC(OC)=CC(OC)=C4)=C3)=O)C=C2)C[C@H](C)N1CC(NCCC5=CC=C(OCC(N[C@@H](C(C)(C)C)C(N6C[C@H](O)C[C@H]6C(N[C@H](C7=CC=C(C8=C(C)N=CS8)C=C7)C)=O)=O)=O)C=C5)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,125.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Guo L, Liu J, Nie X, Wang T, Ma ZX, Yin D, Tang W. Development of selective FGFR1 degraders using a Rapid synthesis of proteolysis targeting Chimera (Rapid-TAC) platform. Bioorg Med Chem Lett. 2022 Nov 1;75:128982. doi: 10.1016/j.bmcl.2022.128982. Epub 2022 Sep 9. PMID: 36096343.