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MedKoo Cat#: 129075 | Name: SKLB-11A
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SKLB-11A is a potent allosteric SIRT3 (sirtuin 3) agonist.

Chemical Structure

SKLB-11A
SKLB-11A
CAS#433953-86-7

Theoretical Analysis

MedKoo Cat#: 129075

Name: SKLB-11A

CAS#: 433953-86-7

Chemical Formula: C19H15FN4O2

Exact Mass: 350.1179

Molecular Weight: 350.35

Elemental Analysis: C, 65.14; H, 4.32; F, 5.42; N, 15.99; O, 9.13

Price and Availability

Size Price Availability Quantity
5mg USD 550.00 2 Weeks
25mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
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Related CAS #
No Data
Synonym
SKLB-11A; SKLB11A; SKLB 11A
IUPAC/Chemical Name
methyl 2-amino-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate
InChi Key
ZIRBXDWXWABLAI-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H15FN4O2/c1-26-19(25)15-16-18(23-14-5-3-2-4-13(14)22-16)24(17(15)21)10-11-6-8-12(20)9-7-11/h2-9H,10,21H2,1H3
SMILES Code
COC(C1=C(N)N(CC2=CC=C(F)C=C2)C3=NC4=CC=CC=C4N=C31)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 350.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Zhang D, Zhang J, Wu C, Xiao Y, Ji L, Hu J, Ding J, Li T, Zhang Y, Ouyang L. Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies. ACS Cent Sci. 2025 Apr 14;11(5):704-718. doi: 10.1021/acscentsci.5c00023. PMID: 40454347; PMCID: PMC12123458.

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