FHND5032 is a miR-124 inducer as a potent therapeutic candidate for lcerative colitis (UC). FHND5032 significantly upregulated miR-124 expression in macrophages, surpassing the clinical-stage comparator ABX464 in vitro and in vivo. FHND5032 markedly reduced the disease activity index, restored colon length, preserved mucosal architecture, and repaired intestinal barrier integrity. Additionally, FHND5032 reversed gut dysbiosis by reducing Proteobacteria and enriching beneficial Firmicutes, outperforming ABX464 in microbiome modulation. Safety assessments confirmed no organ toxicity or biochemical abnormalities.
MedKoo Cat#: 129071
Name: FHND5032
CAS#: N/A
Chemical Formula: C15H9ClF3N3O
Exact Mass: 339.0386
Molecular Weight: 339.70
Elemental Analysis: C, 53.04; H, 2.67; Cl, 10.44; F, 16.78; N, 12.37; O, 4.71
The following data is based on the product molecular weight 339.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
