PF-6142 is a G protein-biased agonist with β-arrestin signaling and measurable receptor internalization.
MedKoo Cat#: 129070
Name: PF-6142
CAS#: N/A
Chemical Formula: C21H16N4O2
Exact Mass: 356.1273
Molecular Weight: 356.39
Elemental Analysis: C, 70.77; H, 4.53; N, 15.72; O, 8.98
The following data is based on the product molecular weight 356.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kozak R, Kiss T, Dlugolenski K, Johnson DE, Gorczyca RR, Kuszpit K, Harvey
BD, Stolyar P, Sukoff Rizzo SJ, Hoffmann WE, Volfson D, Hajós M, Davoren JE,
Abbott AL, Williams GV, Castner SA, Gray DL. Characterization of PF-6142, a
Novel, Non-Catecholamine Dopamine Receptor D1 Agonist, in Murine and Nonhuman
Primate Models of Dopaminergic Activation. Front Pharmacol. 2020 Jul 7;11:1005.
doi: 10.3389/fphar.2020.01005. PMID: 32733245; PMCID: PMC7358525.
2: Nguyen AM, Semeano A, Quach V, Inoue A, Nichols DE, Yano H. Characterization
of Gα<sub>s</sub> and Gα<sub>olf</sub> activation by catechol and non-catechol
dopamine D1 receptor agonists. iScience. 2025 Apr 3;28(5):112345. doi:
10.1016/j.isci.2025.112345. PMID: 40384932; PMCID: PMC12084000.
