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MedKoo Cat#: 129063 | Name: PX20350

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PX20350 is a Farnesoid X receptor agonist.

Chemical Structure

PX20350
PX20350
CAS#1198085-23-2

Theoretical Analysis

MedKoo Cat#: 129063

Name: PX20350

CAS#: 1198085-23-2

Chemical Formula: C28H22Cl2F3N3O4

Exact Mass: 591.0900

Molecular Weight: 592.40

Elemental Analysis: C, 56.77; H, 3.74; Cl, 11.97; F, 9.62; N, 7.09; O, 10.80

Price and Availability

Related CAS #
No Data
Synonym
PX20350; PX 20350; PX-20350
IUPAC/Chemical Name
4-(((6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)(methyl)amino)methyl)benzoic acid
InChi Key
KNWXWQGSCZVUGX-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H22Cl2F3N3O4/c1-36(13-15-5-7-17(8-6-15)27(37)38)21-11-12-22(34-26(21)28(31,32)33)39-14-18-24(35-40-25(18)16-9-10-16)23-19(29)3-2-4-20(23)30/h2-8,11-12,16H,9-10,13-14H2,1H3,(H,37,38)
SMILES Code
CN(C1=C(C(F)(F)F)N=C(OCC2=C(C3CC3)ON=C2C4=C(Cl)C=CC=C4Cl)C=C1)CC5=CC=C(C(O)=O)C=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 592.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

1: Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, Perović-Ottstadt S,

Schulz A, Hahn U, Burnet M, Kremoser C. The nuclear bile acid receptor FXR

controls the liver derived tumor suppressor histidine-rich glycoprotein. Int J

Cancer. 2015 Jun 1;136(11):2693-704. doi: 10.1002/ijc.29312. Epub 2014 Nov 13.

PMID: 25363753.

 

2: Hambruch E, Miyazaki-Anzai S, Hahn U, Matysik S, Boettcher A, Perović-

Ottstadt S, Schlüter T, Kinzel O, Krol HD, Deuschle U, Burnet M, Levi M, Schmitz

G, Miyazaki M, Kremoser C. Synthetic farnesoid X receptor agonists induce high-

density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys

and prevent atherosclerosis in cholesteryl ester transfer protein transgenic

low-density lipoprotein receptor (-/-) mice. J Pharmacol Exp Ther. 2012

Dec;343(3):556-67. doi: 10.1124/jpet.112.196519. Epub 2012 Aug 23. PMID:

22918042; PMCID: PMC11047796.