VNRX-9945 | HBV (AAV-HBV) infection

MedKoo Cat#: 129062 | Name: VNRX-9945

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VNRX-9945 is a Potent, Broadly Active Capsid Assembly Modulator as a Clinical Candidate for the Treatment of Chronic Hepatitis B Virus Infection. VNRX-9945 exhibited excellent and broad antiviral activity against multiple HBV genotypes in vitro, along with favorable pharmacokinetic profiles across multiple species. Additionally, VNRX-9945 demonstrated robust efficacy in the adeno-associated virus mouse model of HBV (AAV-HBV) infection.

Chemical Structure

VNRX-9945

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129062

Name: VNRX-9945

CAS#: N/A

Chemical Formula: C23H30FN3O4

Exact Mass: 431.2200

Molecular Weight: 431.51

Elemental Analysis: C, 64.02; H, 7.01; F, 4.40; N, 9.74; O, 14.83

Price and Availability

Related CAS #

No Data

Synonym

VNRX-9945; VNRX9945; VNRX 9945

IUPAC/Chemical Name

N-(4-fluoro-3-methylphenyl)-5-(2-(((1s,4s)-4-hydroxycyclohexyl)amino)-2-oxoacetyl)-1,2,4-trimethyl-4,5-dihydro-1H-pyrrole-3-carboxamide

InChi Key

UMTDLHOQQGYESX-XOMFUOJCSA-N

InChi Code

InChI=1S/C23H30FN3O4/c1-12-11-16(7-10-18(12)24)26-22(30)19-13(2)20(27(4)14(19)3)21(29)23(31)25-15-5-8-17(28)9-6-15/h7,10-11,13,15,17,20,28H,5-6,8-9H2,1-4H3,(H,25,31)(H,26,30)/t13?,15-,17+,20?

SMILES Code

FC1=CC=C(NC(C2=C(C)N(C)C(C(C(N[C@@H]3CC[C@H](O)CC3)=O)=O)C2C)=O)C=C1C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Biological target:

In vitro activity:

In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 431.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

In vitro protocol:

In vivo protocol:

Discovery of VNRX-9945, a Potent, Broadly Active Capsid Assembly Modulator as a Clinical Candidate for the Treatment of Chronic Hepatitis B Virus Infection

Bin Liu, Jiangchao Yao, Thomas Haimowitz, Christopher A. Benetatos, Steven A. Boyd, Stephen M. Condon, Christopher J. Burns, Andre White, Damodharan Lakshminarasimhan, Robert K. Suto, Ozgur Cakici, Anthony S. Drager, Susan G. Emeigh Hart, Daniel C. Pevear, and Glen A. Coburn

ACS Medicinal Chemistry Letters Article ASAP
DOI: 10.1021/acsmedchemlett.5c00315