MedKoo Cat#: 129052 | Name: ZM-PI05

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZM-PI05 is a PI3K PROTAC degrader.

Chemical Structure

ZM-PI05
ZM-PI05
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129052

Name: ZM-PI05

CAS#: N/A

Chemical Formula: C45H53N13O9

Exact Mass: 919.4100

Molecular Weight: 920.00

Elemental Analysis: C, 58.75; H, 5.81; N, 19.79; O, 15.65

Price and Availability

Related CAS #
No Data
Synonym
ZM-PI05; ZM-PI-05; ZM-PI 05
IUPAC/Chemical Name
2-amino-N-(8-(2-(2-((5-(1-(5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)-1H-1,2,3-triazol-4-yl)pentyl)oxy)ethoxy)ethoxy)-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide
InChi Key
IFQKRASZZOHCJJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C45H53N13O9/c1-64-38-34(14-12-31-37(38)52-45(57-19-17-48-39(31)57)53-40(60)28-25-49-44(46)50-26-28)67-24-23-66-22-21-65-20-7-2-4-9-29-27-56(55-54-29)18-6-3-5-16-47-32-11-8-10-30-36(32)43(63)58(42(30)62)33-13-15-35(59)51-41(33)61/h8,10-12,14,25-27,33,47H,2-7,9,13,15-24H2,1H3,(H2,46,49,50)(H,51,59,61)(H,52,53,60)
SMILES Code
NC1=NC=C(C(NC2=NC3=C(C=CC(OCCOCCOCCCCCC4=CN(CCCCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)N=N4)=C3OC)C8=NCCN28)=O)C=N1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 920.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Zimo Yang, Yan Tong, Yongbo Liu, Qianlong Liu, Zhihao Ni, Yuna He, Yu Rao,

Developing selective PI3K degraders to modulate both kinase and non-kinase functions,

Chinese Chemical Letters,

Volume 35, Issue 11,

2024,

109577,

ISSN 1001-8417,

https://doi.org/10.1016/j.cclet.2024.109577.

(https://www.sciencedirect.com/science/article/pii/S1001841724000974)