WH244 is a second-generation PROTAC that selectively degrades the anti-apoptotic proteins BCL-xL and BCL-2 with a DC50 of 0.6 nM for BCL-xL and 7.4 nM for BCL-2.
MedKoo Cat#: 129021
Name: WH244
CAS#: 2941088-96-4
Chemical Formula: C83H105ClF3N13O11S4
Exact Mass: 1679.6580
Molecular Weight: 1681.52
Elemental Analysis: C, 59.29; H, 6.29; Cl, 2.11; F, 3.39; N, 10.83; O, 10.47; S, 7.63
The following data is based on the product molecular weight 1,681.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
